Assay Report Card

Basic Information

ID: ALA4419455

Type: Binding

Description: Binding affinity to C-terminal FLAG-tagged human ferroportin expressed in Pichia pastoris assessed as reduction in inhibition of binding of TMR-hepcidin to Fpn incubated for 90 mins by fluorescence polarization assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4419455

IC50

Total(185)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
452.56	3.59	3.59
461.42	3.03	3.03
441.95	3.03	3.03
424.51	2.86	2.86
452.97	3.64	3.64
395.49	2.02	2.02
427.51	2.67	2.67
476.61	3.12	3.12
407.45	2.09	2.09
519.86	2.82	2.82
475.50	4.18	4.18
438.53	3.17	3.17
461.38	3.98	3.98
375.44	1.87	1.87
460.49	3.41	3.41
426.93	3.33	3.33
516.89	2.11	2.11
426.43	2.53	2.53
499.83	2.25	2.25
410.48	2.82	2.82
551.88	3.00	3.00
433.49	3.06	3.06
434.48	3.05	3.05
438.53	3.17	3.17
478.48	3.83	3.83
406.52	2.99	2.99
407.45	2.09	2.09
394.41	1.41	1.41
410.48	2.82	2.82
391.50	3.63	3.63
444.42	2.67	2.67
434.57	3.35	3.35
452.56	3.94	3.94
435.51	1.78	1.78
409.88	2.53	2.53
457.51	3.88	3.88
421.44	2.05	2.05
422.51	2.69	2.69
462.55	3.37	3.37
389.46	1.92	1.92
460.87	3.18	3.18
419.46	2.32	2.32
428.47	2.95	2.95
540.67	2.30	2.30
537.85	2.95	2.95
410.48	2.82	2.82
438.46	2.40	2.40
406.52	2.72	2.72
424.51	3.12	3.12
438.44	2.80	2.80
393.48	2.07	2.07
421.48	2.36	2.36
422.46	2.73	2.73
397.53	3.34	3.34
406.52	2.99	2.99
424.89	2.90	2.90
409.49	3.42	3.42
476.43	3.41	3.41
432.55	3.38	3.38
420.54	3.29	3.29
408.44	2.39	2.39
393.43	2.01	2.01
394.41	2.35	2.35
527.91	3.16	3.16
412.40	2.49	2.49
396.45	3.14	3.14
615.74	4.89	4.89
420.45	2.66	2.66
402.46	2.52	2.52
376.42	2.21	2.21
410.48	3.53	3.53
406.52	2.72	2.72
427.92	2.73	2.73
406.52	2.99	2.99
441.95	2.77	2.77
410.87	1.92	1.92
450.54	3.85	3.85
424.51	3.12	3.12
477.59	2.51	2.51
419.46	2.36	2.36
478.60	3.98	3.98
426.43	2.53	2.53
516.89	2.11	2.11
568.33	3.51	3.51
416.51	3.15	3.15
515.90	2.99	2.99
469.37	3.14	3.14
470.96	3.78	3.78
460.61	3.88	3.88
533.89	3.21	3.21
435.56	2.74	2.74
475.45	3.07	3.07
381.47	2.00	2.00
501.87	2.68	2.68
517.82	2.39	2.39
405.44	2.28	2.28
431.53	3.16	3.16
410.48	2.82	2.82
423.91	2.57	2.57
393.48	2.07	2.07
481.60	2.92	2.92
486.96	2.88	2.88
503.79	2.35	2.35
382.45	2.27	2.27
410.87	2.86	2.86
460.49	3.70	3.70
417.50	2.55	2.55
438.44	2.80	2.80
426.93	3.33	3.33
410.48	2.82	2.82
438.53	3.59	3.59
494.36	1.58	1.58
515.42	3.35	3.35
444.92	3.47	3.47
455.98	3.08	3.08
395.49	2.02	2.02
492.50	3.88	3.88
393.48	2.07	2.07
452.97	3.53	3.53
440.96	3.37	3.37
407.50	2.38	2.38
422.51	2.17	2.17
424.51	2.86	2.86
547.92	3.25	3.25
410.48	2.82	2.82
460.49	3.70	3.70
444.42	2.67	2.67
501.87	2.68	2.68
395.49	2.02	2.02
427.48	3.56	3.56
569.87	3.14	3.14
421.53	2.42	2.42
533.89	3.21	3.21
511.41	2.38	2.38
401.47	2.36	2.36
444.92	3.47	3.47
395.49	2.02	2.02
540.63	4.60	4.60
489.65	3.03	3.03
494.93	4.35	4.35
422.51	2.69	2.69
480.61	4.37	4.37
551.88	3.00	3.00
501.87	2.68	2.68
450.54	3.52	3.52
406.52	2.99	2.99
408.49	1.97	1.97
698.46	4.22	4.22
420.45	2.66	2.66
530.91	2.42	2.42
406.52	3.24	3.24
420.45	2.66	2.66
409.52	2.32	2.32
515.90	2.99	2.99
432.55	3.21	3.21
422.51	2.69	2.69
427.92	2.73	2.73
568.68	4.69	4.69
432.55	3.55	3.55
433.49	2.40	2.40
444.42	2.67	2.67
417.54	3.55	3.55
452.56	3.59	3.59
422.46	2.70	2.70
403.45	1.91	1.91
442.88	3.04	3.04
520.85	3.08	3.08
447.52	3.14	3.14
438.44	2.80	2.80
553.30	2.06	2.06
530.91	2.42	2.42
393.48	2.07	2.07
436.52	3.13	3.13
408.44	2.39	2.39
408.44	1.45	1.45
408.49	1.97	1.97
450.54	3.30	3.30
421.48	2.63	2.63
442.50	3.00	3.00
395.49	2.02	2.02
444.56	3.47	3.47
524.88	2.40	2.40
420.54	3.29	3.29
547.92	3.20	3.20
519.86	2.82	2.82