Basic Information
ID: ALA4420671
Type: Binding
Description: Inhibition of LATS in human JHH5 cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Serine/threonine-protein kinase LATS(ALA4523992)
Document: ALA4420070
Inhibition of LATS in human JHH5 cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4420671
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 313.36 | 4.14 | 4.14 |
| 339.40 | 2.29 | 2.29 |
| 279.35 | 3.30 | 3.30 |
| 369.47 | 4.91 | 4.91 |
| 321.34 | 2.36 | 2.36 |
| 293.37 | 3.69 | 3.69 |
| 333.32 | 3.47 | 3.47 |
| 349.32 | 2.81 | 2.81 |
| 311.35 | 1.51 | 1.51 |
| 277.33 | 3.05 | 3.05 |
| 349.39 | 2.98 | 2.98 |
| 363.30 | 2.90 | 2.90 |
| 293.33 | 2.68 | 2.68 |
| 307.36 | 2.68 | 2.68 |
| 251.29 | 2.52 | 2.52 |
| 394.48 | 5.00 | 5.00 |
| 305.39 | 3.69 | 3.69 |
| 265.32 | 2.54 | 2.54 |
| 364.45 | 2.61 | 2.61 |
| 307.36 | 2.41 | 2.41 |
| 335.37 | 2.45 | 2.45 |
| 293.33 | 2.29 | 2.29 |
| 293.37 | 3.69 | 3.69 |
| 309.33 | 2.36 | 2.36 |
| 313.36 | 4.14 | 4.14 |
| 289.34 | 2.91 | 2.91 |
| 317.33 | 3.97 | 3.97 |
| 363.30 | 2.90 | 2.90 |
| 317.33 | 3.97 | 3.97 |
| 309.33 | 2.36 | 2.36 |
| 422.49 | 3.04 | 3.04 |
| 263.30 | 2.66 | 2.66 |
| 329.39 | 2.24 | 2.24 |
| 295.35 | 2.27 | 2.27 |
| 394.48 | 3.80 | 3.80 |
| 307.36 | 2.41 | 2.41 |
| 307.36 | 2.41 | 2.41 |
| 329.36 | 3.84 | 3.84 |
| 265.32 | 2.91 | 2.91 |
| 237.27 | 2.13 | 2.13 |
| 399.54 | 5.49 | 5.49 |
| 347.47 | 4.86 | 4.86 |
| 291.36 | 3.44 | 3.44 |
| 323.40 | 3.31 | 3.31 |
| 309.37 | 2.92 | 2.92 |
| 293.37 | 3.69 | 3.69 |
| 329.39 | 1.54 | 1.54 |
| 265.32 | 2.91 | 2.91 |
| 327.39 | 4.26 | 4.26 |
| 293.37 | 3.32 | 3.32 |
| 333.32 | 3.47 | 3.47 |
| 349.32 | 2.81 | 2.81 |
| 251.29 | 2.15 | 2.15 |
| 331.30 | 3.59 | 3.59 |
| 327.34 | 0.21 | 0.21 |
| 309.37 | 2.66 | 2.66 |
| 363.30 | 2.90 | 2.90 |
| 313.36 | 4.14 | 4.14 |
| 352.40 | 1.95 | 1.95 |
| 333.36 | 1.64 | 1.64 |
| 279.35 | 2.93 | 2.93 |
| 295.35 | 2.27 | 2.27 |
| 299.34 | 3.83 | 3.83 |
| 337.43 | 3.44 | 3.44 |
| 351.45 | 4.09 | 4.09 |
| 341.42 | 4.43 | 4.43 |
| 353.38 | 2.38 | 2.38 |
| 291.36 | 3.44 | 3.44 |
| 337.38 | 3.14 | 3.14 |
| 295.35 | 2.27 | 2.27 |
| 279.35 | 3.30 | 3.30 |
| 363.30 | 2.90 | 2.90 |
| 279.35 | 2.93 | 2.93 |
| 348.45 | 3.05 | 3.05 |
| 377.37 | 3.59 | 3.59 |
| 309.37 | 2.66 | 2.66 |
| 323.40 | 3.05 | 3.05 |
| 364.45 | 2.61 | 2.61 |
| 373.44 | 4.66 | 4.66 |
| 333.32 | 3.84 | 3.84 |
| 333.32 | 3.47 | 3.47 |
| 323.36 | 2.45 | 2.45 |
| 367.45 | 3.06 | 3.06 |
| 323.36 | 2.75 | 2.75 |
| 279.35 | 3.30 | 3.30 |
| 345.33 | 3.98 | 3.98 |
| 335.46 | 4.71 | 4.71 |
| 321.38 | 2.80 | 2.80 |
| 311.35 | 1.24 | 1.24 |
| 359.41 | 4.57 | 4.57 |
| 267.29 | 1.49 | 1.49 |
| 321.34 | 2.51 | 2.51 |
| 317.33 | 3.97 | 3.97 |
| 349.32 | 2.81 | 2.81 |
| 321.38 | 2.80 | 2.80 |
| 357.44 | 2.32 | 2.32 |
| 371.47 | 2.71 | 2.71 |
| 395.39 | 4.67 | 4.67 |
| 293.37 | 3.32 | 3.32 |
| 319.29 | 3.45 | 3.45 |