Basic Information
ID: ALA4421085
Type: Binding
Description: Inhibition of N-terminal 6x-His-tagged recombinant human SOS1 catalytic domain (residues 564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in 50 nM SOS1-mediated GDP/GTP nucleotide exchange upon 2 uM N-terminal-GST-tagged H-Ras (1 to 166 residues) by BODIPY-FL-GDP dissociation assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4421085
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 266.30 | 2.08 | 2.08 |
| 467.52 | 7.76 | 7.76 |
| 378.38 | 4.98 | 4.98 |
| 449.51 | 6.96 | 6.96 |
| 302.28 | 1.32 | 1.32 |
| 307.31 | 3.50 | 3.50 |
| 438.44 | 3.48 | 3.48 |
| 370.45 | 7.69 | 7.69 |
| 347.42 | 5.91 | 5.91 |
| 415.51 | 5.90 | 5.90 |
| 378.20 | 4.39 | 4.39 |
| 422.42 | 2.14 | 2.14 |
| 362.43 | 6.60 | 6.60 |
| 356.43 | 4.00 | 4.00 |
| 325.80 | 4.86 | 4.86 |
| 348.40 | 6.51 | 6.51 |
| 385.51 | 5.89 | 5.89 |
| 293.37 | 3.54 | 3.54 |
| 392.39 | 2.14 | 2.14 |
| 373.41 | 2.51 | 2.51 |
| 403.91 | 5.93 | 5.93 |
| 436.45 | 2.45 | 2.45 |
| 474.36 | 4.07 | 4.07 |
| 432.43 | 6.32 | 6.32 |
| 378.39 | 0.65 | 0.65 |
| 406.42 | 2.44 | 2.44 |
| 325.80 | 4.86 | 4.86 |
| 372.43 | 4.01 | 4.01 |
| 376.39 | 2.43 | 2.43 |
| 480.45 | 7.44 | 7.44 |
| 358.40 | 3.71 | 3.71 |
| 293.37 | 3.54 | 3.54 |
| 414.46 | 5.19 | 5.19 |
| 403.91 | 5.93 | 5.93 |
| 438.80 | 7.00 | 7.00 |
| 412.39 | 1.55 | 1.55 |