Basic Information
ID: ALA4421135
Type: Binding
Description: Inhibition of N-terminal 6x-His-tagged recombinant human SOS1 catalytic domain (residues 564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in 50 nM SOS1-mediated GDP/GTP nucleotide exchange upon 2 uM N-terminal-GST-tagged H-Ras (1 to 166 residues) at 20 uM by BODIPY-FL-GDP dissociation assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4421135
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 403.91 | 5.93 | 5.93 |