Basic Information
ID: ALA4421137
Type: Binding
Description: Inhibition of N-terminal 6x-His-tagged recombinant human ITSN1 DH and PH domain (1227 to 1571 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in 50 nM SOS1-mediated GDP/GTP nucleotide exchange upon 2 uM N-terminal-GST-tagged Cdc42 (1 to 182 residues) at 20 uM by BODIPY-FL-GDP dissociation assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4421137
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 403.91 | 5.93 | 5.93 |