Basic Information
ID: ALA4421312
Type: Binding
Description: Inhibition of GST-tagged SOS1 (564 to 1049 amino acids) (unknown origin) assessed as reduction SOS1/6xHis-Tev-tagged K-Ras G12D mutant (1 to 169 residues) interaction incubated for 30 mins by AlphaLISA method
Format: BAO_0000357
Organism: Homo sapiens
Target: Son of sevenless homolog 1(ALA2079846)
Document: ALA4420081
Inhibition of GST-tagged SOS1 (564 to 1049 amino acids) (unknown origin) assessed as reduction SOS1/6xHis-Tev-tagged K-Ras G12D mutant (1 to 169 residues) interaction incubated for 30 mins by AlphaLISA method: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4421312
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 504.68 | 5.71 | 5.71 |
| 526.56 | 5.15 | 5.15 |
| 430.60 | 5.78 | 5.78 |
| 460.50 | 5.38 | 5.38 |
| 432.57 | 4.99 | 4.99 |
| 408.57 | 5.34 | 5.34 |
| 446.47 | 5.30 | 5.30 |
| 499.58 | 6.07 | 6.07 |
| 492.57 | 5.31 | 5.31 |
| 455.56 | 4.34 | 4.34 |
| 467.50 | 5.39 | 5.39 |
| 584.69 | 5.77 | 5.77 |
| 446.60 | 5.08 | 5.08 |
| 492.57 | 5.31 | 5.31 |
| 496.53 | 5.14 | 5.14 |
| 526.58 | 4.47 | 4.47 |
| 481.52 | 5.87 | 5.87 |
| 495.51 | 4.70 | 4.70 |
| 416.61 | 6.32 | 6.32 |
| 571.64 | 5.85 | 5.85 |
| 444.62 | 5.70 | 5.70 |
| 432.57 | 4.77 | 4.77 |
| 460.62 | 5.79 | 5.79 |
| 557.66 | 6.22 | 6.22 |
| 485.59 | 4.35 | 4.35 |
| 485.59 | 4.35 | 4.35 |
| 601.71 | 6.53 | 6.53 |
| 416.57 | 5.45 | 5.45 |
| 555.64 | 6.23 | 6.23 |
| 499.58 | 5.40 | 5.40 |
| 513.61 | 6.38 | 6.38 |
| 467.62 | 5.68 | 5.68 |
| 460.50 | 5.61 | 5.61 |
| 432.57 | 5.15 | 5.15 |
| 571.64 | 5.85 | 5.85 |
| 529.61 | 5.44 | 5.44 |
| 568.69 | 6.07 | 6.07 |
| 529.61 | 6.08 | 6.08 |
| 501.55 | 5.06 | 5.06 |
| 439.58 | 4.72 | 4.72 |
| 428.49 | 4.33 | 4.33 |
| 511.55 | 6.13 | 6.13 |
| 543.63 | 5.83 | 5.83 |
| 408.57 | 5.34 | 5.34 |
| 490.55 | 5.22 | 5.22 |
| 486.54 | 5.91 | 5.91 |
| 515.58 | 5.37 | 5.37 |
| 519.54 | 5.59 | 5.59 |
| 478.54 | 5.00 | 5.00 |
| 496.56 | 4.84 | 4.84 |
| 455.56 | 4.34 | 4.34 |
| 573.66 | 6.10 | 6.10 |
| 529.61 | 6.08 | 6.08 |
| 472.63 | 5.29 | 5.29 |
| 486.54 | 5.86 | 5.86 |
| 472.51 | 5.39 | 5.39 |
| 587.69 | 6.14 | 6.14 |
| 446.60 | 5.08 | 5.08 |
| 444.50 | 5.68 | 5.68 |
| 524.61 | 5.48 | 5.48 |
| 501.55 | 5.45 | 5.45 |
| 416.57 | 5.45 | 5.45 |
| 555.64 | 6.23 | 6.23 |
| 514.60 | 4.98 | 4.98 |
| 543.63 | 5.83 | 5.83 |
| 497.52 | 5.57 | 5.57 |
| 543.63 | 5.83 | 5.83 |
| 528.62 | 6.81 | 6.81 |
| 543.63 | 6.39 | 6.39 |
| 430.47 | 5.37 | 5.37 |
| 408.57 | 5.34 | 5.34 |
| 481.52 | 5.87 | 5.87 |
| 432.57 | 4.99 | 4.99 |
| 529.61 | 5.44 | 5.44 |
| 456.51 | 5.86 | 5.86 |
| 513.61 | 6.38 | 6.38 |
| 573.66 | 6.10 | 6.10 |
| 584.69 | 5.77 | 5.77 |
| 416.61 | 6.32 | 6.32 |
| 476.50 | 5.31 | 5.31 |
| 470.54 | 6.21 | 6.21 |
| 481.48 | 4.44 | 4.44 |
| 462.59 | 4.78 | 4.78 |
| 558.65 | 6.17 | 6.17 |
| 512.50 | 6.61 | 6.61 |
| 568.69 | 6.07 | 6.07 |
| 492.57 | 5.31 | 5.31 |
| 513.61 | 6.46 | 6.46 |
| 509.53 | 5.05 | 5.05 |
| 531.58 | 5.07 | 5.07 |
| 482.46 | 5.04 | 5.04 |
| 499.58 | 6.07 | 6.07 |
| 496.53 | 5.14 | 5.14 |
| 549.57 | 5.21 | 5.21 |
| 509.53 | 5.05 | 5.05 |
| 573.66 | 5.75 | 5.75 |
| 490.65 | 5.54 | 5.54 |
| 573.66 | 5.75 | 5.75 |
| 557.66 | 6.22 | 6.22 |
| 543.63 | 5.83 | 5.83 |