Basic Information
ID: ALA4421312
Type: Binding
Description: Inhibition of GST-tagged SOS1 (564 to 1049 amino acids) (unknown origin) assessed as reduction SOS1/6xHis-Tev-tagged K-Ras G12D mutant (1 to 169 residues) interaction incubated for 30 mins by AlphaLISA method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4421312
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 504.68 | 5.71 | 5.71 |
| 503.53 | 4.72 | 4.72 |
| 384.48 | 4.79 | 4.79 |
| 480.61 | 5.87 | 5.87 |
| 526.56 | 5.15 | 5.15 |
| 445.49 | 5.25 | 5.25 |
| 430.60 | 5.78 | 5.78 |
| 460.50 | 5.38 | 5.38 |
| 543.63 | 6.39 | 6.39 |
| 472.51 | 4.96 | 4.96 |
| 455.56 | 5.19 | 5.19 |
| 445.49 | 5.25 | 5.25 |
| 432.57 | 4.99 | 4.99 |
| 412.46 | 5.51 | 5.51 |
| 408.57 | 5.34 | 5.34 |
| 446.47 | 5.30 | 5.30 |
| 499.58 | 6.07 | 6.07 |
| 487.53 | 5.02 | 5.02 |
| 492.57 | 5.31 | 5.31 |
| 455.56 | 4.34 | 4.34 |
| 501.55 | 5.41 | 5.41 |
| 459.51 | 5.56 | 5.56 |
| 409.56 | 4.71 | 4.71 |
| 428.54 | 4.37 | 4.37 |
| 482.55 | 6.40 | 6.40 |
| 424.43 | 5.49 | 5.49 |
| 513.56 | 5.41 | 5.41 |
| 467.50 | 5.39 | 5.39 |
| 584.69 | 5.77 | 5.77 |
| 480.49 | 5.64 | 5.64 |
| 498.55 | 5.27 | 5.27 |
| 375.52 | 5.44 | 5.44 |
| 509.53 | 5.90 | 5.90 |
| 446.47 | 5.19 | 5.19 |
| 446.60 | 5.08 | 5.08 |
| 476.50 | 5.20 | 5.20 |
| 492.57 | 5.31 | 5.31 |
| 496.53 | 5.14 | 5.14 |
| 537.63 | 6.09 | 6.09 |
| 526.58 | 4.47 | 4.47 |
| 481.52 | 5.87 | 5.87 |
| 495.51 | 4.70 | 4.70 |
| 547.60 | 6.22 | 6.22 |
| 416.61 | 6.32 | 6.32 |
| 522.57 | 6.82 | 6.82 |
| 571.64 | 5.85 | 5.85 |
| 444.62 | 5.70 | 5.70 |
| 415.46 | 6.02 | 6.02 |
| 538.57 | 5.87 | 5.87 |
| 471.46 | 5.22 | 5.22 |
| 502.54 | 4.59 | 4.59 |
| 400.48 | 4.78 | 4.78 |
| 432.57 | 4.77 | 4.77 |
| 528.60 | 4.56 | 4.56 |
| 460.62 | 5.79 | 5.79 |
| 557.66 | 6.22 | 6.22 |
| 485.59 | 4.35 | 4.35 |
| 574.64 | 5.22 | 5.22 |
| 485.59 | 4.35 | 4.35 |
| 548.58 | 5.74 | 5.74 |
| 482.51 | 5.08 | 5.08 |
| 601.71 | 6.53 | 6.53 |
| 416.57 | 5.45 | 5.45 |
| 459.51 | 5.56 | 5.56 |
| 451.52 | 3.51 | 3.51 |
| 555.64 | 6.23 | 6.23 |
| 488.51 | 5.14 | 5.14 |
| 513.61 | 6.46 | 6.46 |
| 499.58 | 5.40 | 5.40 |
| 513.61 | 6.38 | 6.38 |
| 467.62 | 5.68 | 5.68 |
| 491.49 | 4.85 | 4.85 |
| 460.50 | 5.61 | 5.61 |
| 560.62 | 4.97 | 4.97 |
| 432.57 | 5.15 | 5.15 |
| 571.64 | 5.85 | 5.85 |
| 444.50 | 5.73 | 5.73 |
| 374.53 | 5.20 | 5.20 |
| 529.61 | 5.44 | 5.44 |
| 568.69 | 6.07 | 6.07 |
| 534.55 | 5.42 | 5.42 |
| 529.61 | 6.08 | 6.08 |
| 490.60 | 4.06 | 4.06 |
| 396.90 | 5.28 | 5.28 |
| 488.59 | 3.97 | 3.97 |
| 514.57 | 6.58 | 6.58 |
| 501.55 | 5.06 | 5.06 |
| 481.48 | 4.92 | 4.92 |
| 439.58 | 4.72 | 4.72 |
| 428.49 | 4.33 | 4.33 |
| 511.55 | 6.13 | 6.13 |
| 543.63 | 5.83 | 5.83 |
| 498.63 | 5.09 | 5.09 |
| 498.57 | 4.93 | 4.93 |
| 408.57 | 5.34 | 5.34 |
| 490.55 | 5.22 | 5.22 |
| 398.51 | 5.09 | 5.09 |
| 501.48 | 5.23 | 5.23 |
| 486.54 | 5.91 | 5.91 |
| 543.63 | 6.09 | 6.09 |
| 370.46 | 4.78 | 4.78 |
| 515.58 | 5.37 | 5.37 |
| 434.54 | 4.43 | 4.43 |
| 519.54 | 5.59 | 5.59 |
| 478.54 | 5.00 | 5.00 |
| 496.56 | 4.84 | 4.84 |
| 480.54 | 5.92 | 5.92 |
| 455.56 | 4.34 | 4.34 |
| 475.51 | 5.26 | 5.26 |
| 573.66 | 6.10 | 6.10 |
| 463.48 | 5.39 | 5.39 |
| 454.50 | 5.77 | 5.77 |
| 538.57 | 6.52 | 6.52 |
| 509.53 | 5.90 | 5.90 |
| 529.61 | 6.08 | 6.08 |
| 472.63 | 5.29 | 5.29 |
| 479.52 | 4.53 | 4.53 |
| 526.60 | 6.26 | 6.26 |
| 486.54 | 5.27 | 5.27 |
| 493.50 | 5.40 | 5.40 |
| 486.54 | 5.86 | 5.86 |
| 462.47 | 4.89 | 4.89 |
| 472.51 | 5.39 | 5.39 |
| 587.69 | 6.14 | 6.14 |
| 574.64 | 5.36 | 5.36 |
| 446.60 | 5.08 | 5.08 |
| 414.48 | 5.60 | 5.60 |
| 418.54 | 4.25 | 4.25 |
| 501.55 | 5.10 | 5.10 |
| 444.50 | 5.68 | 5.68 |
| 524.61 | 5.48 | 5.48 |
| 501.55 | 5.45 | 5.45 |
| 453.47 | 5.08 | 5.08 |
| 500.57 | 5.60 | 5.60 |
| 416.57 | 5.45 | 5.45 |
| 555.64 | 6.23 | 6.23 |
| 499.54 | 4.97 | 4.97 |
| 527.55 | 4.67 | 4.67 |
| 514.60 | 4.98 | 4.98 |
| 412.50 | 4.63 | 4.63 |
| 487.52 | 5.82 | 5.82 |
| 541.62 | 5.84 | 5.84 |
| 459.49 | 4.37 | 4.37 |
| 543.63 | 5.83 | 5.83 |
| 554.57 | 4.85 | 4.85 |
| 457.55 | 3.69 | 3.69 |
| 550.55 | 4.73 | 4.73 |
| 497.52 | 5.57 | 5.57 |
| 555.64 | 6.23 | 6.23 |
| 543.63 | 5.83 | 5.83 |
| 502.54 | 4.97 | 4.97 |
| 467.50 | 5.39 | 5.39 |
| 497.53 | 4.66 | 4.66 |
| 528.62 | 6.81 | 6.81 |
| 543.63 | 6.39 | 6.39 |
| 430.47 | 5.37 | 5.37 |
| 408.57 | 5.34 | 5.34 |
| 360.51 | 4.89 | 4.89 |
| 598.71 | 5.78 | 5.78 |
| 459.49 | 4.37 | 4.37 |
| 481.52 | 5.87 | 5.87 |
| 432.57 | 4.99 | 4.99 |
| 529.61 | 5.44 | 5.44 |
| 456.51 | 5.86 | 5.86 |
| 513.61 | 6.38 | 6.38 |
| 463.48 | 5.39 | 5.39 |
| 520.53 | 5.11 | 5.11 |
| 484.57 | 6.49 | 6.49 |
| 555.64 | 6.23 | 6.23 |
| 439.44 | 5.07 | 5.07 |
| 573.66 | 6.10 | 6.10 |
| 584.69 | 5.77 | 5.77 |
| 416.61 | 6.32 | 6.32 |
| 476.50 | 5.31 | 5.31 |
| 393.56 | 5.05 | 5.05 |
| 512.58 | 5.74 | 5.74 |
| 444.50 | 5.73 | 5.73 |
| 470.54 | 6.21 | 6.21 |
| 481.48 | 4.44 | 4.44 |
| 462.59 | 4.78 | 4.78 |
| 646.73 | 5.92 | 5.92 |
| 558.65 | 6.17 | 6.17 |
| 512.50 | 6.61 | 6.61 |
| 378.91 | 5.14 | 5.14 |
| 466.47 | 5.34 | 5.34 |
| 457.52 | 5.10 | 5.10 |
| 598.71 | 5.78 | 5.78 |
| 452.48 | 5.80 | 5.80 |
| 480.46 | 5.03 | 5.03 |
| 568.69 | 6.07 | 6.07 |
| 492.57 | 5.31 | 5.31 |
| 462.47 | 4.89 | 4.89 |
| 547.60 | 6.22 | 6.22 |
| 483.49 | 5.09 | 5.09 |
| 513.61 | 6.46 | 6.46 |
| 509.53 | 5.05 | 5.05 |
| 532.56 | 4.60 | 4.60 |
| 526.60 | 6.26 | 6.26 |
| 531.58 | 5.07 | 5.07 |
| 541.62 | 5.84 | 5.84 |
| 482.46 | 5.04 | 5.04 |
| 499.58 | 6.07 | 6.07 |
| 361.49 | 5.31 | 5.31 |
| 646.73 | 5.92 | 5.92 |
| 496.53 | 5.14 | 5.14 |
| 543.63 | 6.09 | 6.09 |
| 549.57 | 5.21 | 5.21 |
| 509.53 | 5.05 | 5.05 |
| 573.66 | 5.75 | 5.75 |
| 490.65 | 5.54 | 5.54 |
| 573.66 | 5.75 | 5.75 |
| 550.58 | 6.28 | 6.28 |
| 557.66 | 6.22 | 6.22 |
| 543.63 | 5.83 | 5.83 |