Basic Information
ID: ALA4421319
Type: Binding
Description: Inhibition of SOS1 in human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at assessed as suppression of increase in MEK1/2 phosphorylation at Ser 217/221 residues at 1 uM in presence of 25 to 50 nM trametinib incubated for 2 to 8 hrs by Western blotting analysis
Format: BAO_0000219
Organism: Homo sapiens
Target: Son of sevenless homolog 1(ALA2079846)
Document: ALA4420081
Inhibition of SOS1 in human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at assessed as suppression of increase in MEK1/2 phosphorylation at Ser 217/221 residues at 1 uM in presence of 25 to 50 nM trametinib incubated for 2 to 8 hrs by Western blotting analysis: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4421319
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 462.47 | 4.89 | 4.89 |