Basic Information
ID: ALA4421913
Type: Binding
Description: Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as residual enzyme activity for geranylgeranylation of K-Ras4B at 50 uM incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay relative to control
Format: BAO_0000019
Organism: Rattus norvegicus
Target: Unchecked(ALA612545)
Document: ALA4421722
Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as residual enzyme activity for geranylgeranylation of K-Ras4B at 50 uM incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay relative to control: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4421913
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 528.03 | 5.55 | 5.55 |
| 510.06 | 6.66 | 6.66 |
| 496.03 | 6.10 | 6.10 |
| 502.42 | 6.19 | 6.19 |
| 522.84 | 6.53 | 6.53 |
| 502.42 | 6.19 | 6.19 |
| 512.03 | 5.94 | 5.94 |
| 467.97 | 5.54 | 5.54 |
| 498.00 | 5.55 | 5.55 |
| 511.98 | 5.27 | 5.27 |
| 482.00 | 5.84 | 5.84 |
| 518.42 | 5.89 | 5.89 |
| 502.42 | 6.19 | 6.19 |
| 482.00 | 5.84 | 5.84 |
| 482.00 | 5.84 | 5.84 |
| 465.55 | 5.33 | 5.33 |
| 498.00 | 5.55 | 5.55 |
| 474.00 | 5.60 | 5.60 |
| 536.86 | 6.84 | 6.84 |
| 465.55 | 5.33 | 5.33 |
| 512.43 | 5.65 | 5.65 |
| 467.97 | 5.54 | 5.54 |
| 543.68 | 5.92 | 5.92 |
| 656.69 | 7.53 | 7.53 |
| 405.90 | 4.11 | 4.11 |
| 534.14 | 6.33 | 6.33 |
| 580.56 | 6.63 | 6.63 |
| 484.64 | 4.63 | 4.63 |
| 520.41 | 6.33 | 6.33 |
| 526.72 | 5.94 | 5.94 |
| 485.96 | 5.68 | 5.68 |
| 467.52 | 4.72 | 4.72 |
| 561.77 | 6.09 | 6.09 |
| 512.43 | 5.65 | 5.65 |
| 391.88 | 3.80 | 3.80 |
| 485.96 | 5.68 | 5.68 |
| 481.55 | 5.03 | 5.03 |
| 457.55 | 5.08 | 5.08 |
| 494.08 | 5.55 | 5.55 |
| 568.59 | 6.98 | 6.98 |
| 476.53 | 4.89 | 4.89 |
| 481.55 | 5.03 | 5.03 |
| 495.57 | 5.42 | 5.42 |
| 375.42 | 3.28 | 3.28 |
| 526.45 | 5.95 | 5.95 |
| 479.57 | 5.58 | 5.58 |
| 483.97 | 5.24 | 5.24 |
| 502.42 | 6.19 | 6.19 |
| 542.55 | 6.59 | 6.59 |
| 608.22 | 6.57 | 6.57 |
| 527.68 | 6.22 | 6.22 |
| 565.73 | 5.58 | 5.58 |
| 517.69 | 5.82 | 5.82 |
| 469.51 | 5.16 | 5.16 |
| 498.00 | 5.55 | 5.55 |
| 510.12 | 5.96 | 5.96 |
| 511.57 | 5.04 | 5.04 |
| 602.60 | 6.36 | 6.36 |
| 409.87 | 3.94 | 3.94 |
| 557.71 | 6.31 | 6.31 |
| 530.42 | 5.78 | 5.78 |
| 467.97 | 5.54 | 5.54 |
| 451.52 | 5.02 | 5.02 |
| 546.87 | 6.30 | 6.30 |
| 465.55 | 5.33 | 5.33 |
| 469.51 | 5.16 | 5.16 |
| 495.53 | 4.75 | 4.75 |
| 481.55 | 5.03 | 5.03 |
| 485.96 | 5.68 | 5.68 |
| 485.96 | 5.68 | 5.68 |
| 485.96 | 5.68 | 5.68 |
| 541.71 | 6.61 | 6.61 |
| 501.96 | 5.38 | 5.38 |
| 469.51 | 5.16 | 5.16 |
| 521.72 | 6.43 | 6.43 |
| 536.16 | 6.72 | 6.72 |
| 485.96 | 5.68 | 5.68 |
| 602.60 | 6.44 | 6.44 |
| 526.01 | 5.32 | 5.32 |
| 451.52 | 5.02 | 5.02 |
| 509.56 | 4.81 | 4.81 |
| 642.67 | 7.22 | 7.22 |
| 492.98 | 5.41 | 5.41 |
| 554.78 | 6.70 | 6.70 |
| 485.96 | 5.68 | 5.68 |
| 493.60 | 6.15 | 6.15 |
| 507.69 | 6.04 | 6.04 |
| 580.61 | 6.83 | 6.83 |
| 485.96 | 5.68 | 5.68 |
| 570.60 | 7.38 | 7.38 |
| 594.58 | 7.09 | 7.09 |
| 508.11 | 5.94 | 5.94 |
| 605.79 | 6.36 | 6.36 |
| 538.53 | 5.66 | 5.66 |
| 572.19 | 7.59 | 7.59 |
| 506.38 | 6.02 | 6.02 |
| 426.32 | 4.45 | 4.45 |
| 620.66 | 8.56 | 8.56 |
| 389.45 | 3.59 | 3.59 |
| 622.25 | 6.88 | 6.88 |