Assay Report Card

Basic Information

ID: ALA4421913

Type: Binding

Description: Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as residual enzyme activity for geranylgeranylation of K-Ras4B at 50 uM incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay relative to control

Organism: Rattus norvegicus

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
503.666.496.49
501.965.385.38
482.005.845.84
528.035.555.55
524.086.836.83
495.534.754.75
493.606.156.15
510.066.666.66
518.425.895.89
496.036.106.10
496.036.106.10
502.426.196.19
522.846.536.53
502.426.196.19
512.035.945.94
498.005.555.55
558.537.497.49
481.555.035.03
485.965.685.68
498.005.555.55
467.975.545.54
502.426.196.19
506.386.026.02
502.426.196.19
474.005.605.60
498.005.555.55
531.727.307.30
511.575.045.04
482.005.845.84
511.985.275.27
524.086.836.83
479.575.585.58
520.416.336.33
510.066.666.66
495.575.425.42
517.696.746.74
482.005.845.84
495.676.246.24
546.876.306.30
546.876.306.30
516.456.506.50
512.035.945.94
485.965.685.68
518.425.895.89
482.005.845.84
453.595.255.25
502.426.196.19
482.005.845.84
536.866.846.84
549.696.206.20
546.876.306.30
526.455.955.95
581.326.956.95
489.646.316.31
482.005.845.84
475.615.755.75
540.486.216.21
533.655.915.91
542.455.655.65
526.455.955.95
518.455.715.71
465.555.335.33
554.516.776.77
482.005.845.84
567.296.646.64
526.455.955.95
502.426.196.19
465.555.335.33
498.005.555.55
465.555.335.33
528.035.555.55
474.005.605.60
507.615.215.21
511.985.275.27
572.485.665.66
485.965.685.68
461.585.505.50
491.574.924.92
482.005.845.84
481.555.035.03
461.585.505.50
457.555.085.08
477.585.205.20
482.005.845.84
465.555.335.33
477.585.205.20
536.866.846.84
556.435.375.37
459.564.184.18
542.455.655.65
461.585.505.50
571.725.165.16
530.425.785.78
585.745.205.20
528.425.355.35
447.565.195.19
461.655.125.12
536.506.306.30
417.504.314.31
537.756.436.43
498.005.555.55
505.645.885.88
556.486.046.04
454.014.614.61
560.546.066.06
371.463.453.45
481.645.305.30
461.614.134.13
510.085.235.23
482.005.845.84
489.646.316.31
489.646.186.18
497.645.005.00
470.014.314.31
461.655.045.04
496.095.785.78
482.005.845.84
591.326.416.41
526.015.325.32
371.522.912.91
567.776.446.44
511.675.145.14
465.555.335.33
523.674.374.37
548.085.355.35
405.904.114.11
433.964.824.82
477.654.744.74
453.595.255.25
481.645.305.30
487.695.445.44
465.555.335.33
413.544.444.44
512.435.655.65
540.486.216.21
554.576.286.28
540.555.745.74
465.555.335.33
527.665.015.01
516.085.795.79
533.696.586.58
546.116.046.04
447.565.195.19
552.506.006.00
436.333.913.91
475.685.435.43
447.565.195.19
510.126.176.17
369.493.953.95
357.433.423.42
570.465.435.43
503.695.275.27
467.975.545.54
385.493.763.76
543.685.925.92
454.014.364.36
587.725.035.03
481.555.035.03
461.654.914.91
495.675.185.18
525.655.035.03
461.654.904.90
622.256.886.88
499.635.275.27
530.425.785.78
413.614.084.08
656.697.537.53
447.583.823.82
435.573.653.65
560.095.525.52
476.534.894.89
527.665.015.01
477.654.604.60
389.904.304.30
565.755.545.54
405.904.114.11
475.685.515.51
497.645.005.00
521.705.145.14
479.623.973.97
389.453.593.59
419.573.953.95
434.364.414.41
481.645.305.30
433.604.264.26
524.086.836.83
566.536.146.14
496.095.785.78
530.115.835.83
534.146.336.33
572.197.087.08
580.566.636.63
389.904.304.30
530.116.106.10
568.536.946.94
534.075.935.93
519.695.245.24
484.644.634.63
520.416.336.33
576.145.805.80
497.645.005.00
524.086.836.83
468.045.005.00
461.585.505.50
419.573.953.95
503.666.496.49
489.705.825.82
526.725.945.94
546.116.046.04
525.695.185.18
485.965.685.68
530.425.785.78
447.624.654.65
467.524.724.72
433.604.344.34
482.075.395.39
561.776.096.09
512.435.655.65
463.624.354.35
509.695.485.48
498.005.555.55
532.085.655.65
516.085.955.95
594.986.556.55
510.126.176.17
475.685.305.30
449.593.963.96
485.965.685.68
467.614.994.99
391.883.803.80
355.463.653.65
516.085.955.95
539.725.575.57
530.115.835.83
551.735.155.15
485.965.685.68
505.705.525.52
547.675.975.97
449.593.963.96
481.645.305.30
588.196.786.78
507.636.326.32
532.085.495.49
511.675.315.31
496.095.635.63
482.075.395.39
481.555.035.03
495.675.615.61
526.525.505.50
509.695.485.48
454.014.614.61
477.625.025.02
457.555.085.08
491.684.994.99
494.085.555.55
553.756.136.13
511.675.145.14
463.564.894.89
568.596.986.98
532.085.655.65
482.075.245.24
526.455.955.95
551.776.746.74
574.565.945.94
436.333.913.91
540.555.895.89
494.085.535.53
371.463.353.35
485.965.685.68
580.956.416.41
459.634.684.68
465.555.335.33
447.624.594.59
476.534.894.89
447.624.654.65
369.493.953.95
439.994.224.22
576.535.765.76
520.055.785.78
530.425.785.78
469.515.165.16
516.085.795.79
481.555.035.03
431.584.124.12
546.876.306.30
447.624.734.73
483.614.694.69
482.075.245.24
495.575.425.42
546.876.306.30
511.675.145.14
511.675.395.39
451.525.025.02
555.746.576.57
466.024.774.77
627.836.466.46
532.085.655.65
375.423.283.28
526.455.955.95
516.456.506.50
375.423.283.28
431.584.124.12
479.575.585.58
483.975.245.24
546.115.805.80
491.684.994.99
477.654.744.74
400.463.553.55
502.426.196.19
505.594.984.98
567.296.646.64
505.705.525.52
572.197.087.08
463.624.434.43
512.095.485.48
523.725.745.74
510.126.176.17
477.654.684.68
557.695.025.02
357.484.094.09
435.573.573.57
542.556.596.59
449.594.044.04
509.695.705.70
608.226.576.57
527.686.226.22
519.694.894.89
565.735.585.58
550.536.446.44
491.685.135.13
482.075.245.24
461.654.904.90
477.604.074.07
517.695.825.82
469.515.165.16
498.005.555.55
516.085.795.79
516.085.795.79
461.654.984.98
447.624.594.59
479.645.125.12
527.665.015.01
510.125.965.96
465.555.335.33
541.786.806.80
581.326.956.95
361.493.713.71
526.455.955.95
511.575.045.04
496.095.635.63
542.455.655.65
602.606.366.36
532.085.655.65
459.634.884.88
409.873.943.94
405.904.114.11
557.716.316.31
445.543.673.67
511.624.724.72
497.645.005.00
491.684.994.99
530.425.785.78
385.493.653.65
530.116.216.21
514.656.056.05
546.075.375.37
405.524.804.80
470.774.564.56
397.544.774.77
491.615.595.59
454.014.614.61
544.146.356.35
465.555.335.33
532.085.655.65
463.624.294.29
503.666.496.49
521.705.005.00
449.593.963.96
536.506.306.30
489.646.186.18
477.654.604.60
343.453.703.70
509.653.983.98
475.685.155.15
385.553.303.30
550.536.446.44
581.806.836.83
447.565.195.19
530.425.785.78
481.645.135.13
509.695.865.86
540.086.536.53
415.513.663.66
467.975.545.54
541.654.734.73
451.525.025.02
502.065.655.65
546.876.306.30
550.536.446.44
470.774.564.56
405.904.114.11
449.574.264.26
465.555.335.33
546.876.306.30
437.564.094.09
542.455.655.65
493.654.364.36
606.165.815.81
567.776.446.44
496.095.635.63
479.645.265.26
469.515.165.16
489.664.884.88
482.075.395.39
507.636.326.32
502.065.655.65
495.534.754.75
461.614.134.13
483.975.245.24
537.445.525.52
419.573.873.87
481.555.035.03
477.654.604.60
536.506.306.30
530.115.835.83
482.005.845.84
532.085.655.65
502.426.196.19
497.644.834.83
495.675.445.44
556.486.046.04
461.614.134.13
505.664.854.85
491.634.464.46
497.645.005.00
454.014.614.61
597.806.456.45
562.115.665.66
591.326.416.41
485.965.685.68
461.585.505.50
433.603.753.75
482.075.245.24
535.735.535.53
385.493.763.76
466.024.774.77
459.634.884.88
485.965.685.68
475.634.524.52
571.725.335.33
516.085.955.95
391.883.803.80
485.965.685.68
489.705.825.82
494.085.535.53
518.065.355.35
507.636.326.32
532.085.655.65
502.426.196.19
502.426.196.19
519.666.196.19
463.624.354.35
526.525.355.35
537.445.525.52
519.666.196.19
542.455.655.65
473.665.185.18
505.664.714.71
507.615.215.21
525.695.185.18
493.675.655.65
419.573.703.70
512.435.655.65
530.425.785.78
477.585.205.20
447.624.734.73
445.614.434.43
369.493.953.95
510.484.884.88
427.574.754.75
475.593.853.85
467.975.545.54
536.506.306.30
371.463.453.45
551.735.015.01
527.665.015.01
491.574.924.92
541.716.616.61
461.655.125.12
468.045.005.00
463.624.354.35
516.085.795.79
477.654.744.74
399.583.693.69
592.145.675.67
463.564.894.89
519.735.915.91
482.024.474.47
472.575.065.06
525.654.864.86
467.975.545.54
369.512.692.69
495.675.615.61
463.583.683.68
546.115.805.80
461.585.505.50
409.873.943.94
447.624.524.52
525.695.565.56
501.965.385.38
389.904.304.30
513.665.325.32
526.455.955.95
495.675.185.18
293.392.222.22
491.685.215.21
482.005.845.84
551.776.746.74
511.675.315.31
433.604.344.34
477.585.205.20
491.634.144.14
465.555.335.33
477.585.205.20
541.695.155.15
507.674.614.61
469.515.165.16
521.726.436.43
491.634.324.32
518.455.715.71
536.166.726.72
512.095.335.33
526.455.955.95
485.965.685.68
602.606.446.44
560.146.196.19
373.453.793.79
519.666.196.19
511.675.315.31
521.664.154.15
546.115.805.80
498.075.095.09
510.126.176.17
495.675.555.55
502.065.655.65
516.085.955.95
526.015.325.32
485.965.685.68
496.095.635.63
557.695.025.02
550.536.446.44
468.045.005.00
466.024.774.77
469.515.165.16
530.115.835.83
555.725.195.19
385.553.163.16
461.654.984.98
496.095.785.78
473.665.185.18
497.645.005.00
451.525.025.02
426.324.454.45
538.535.645.64
541.695.405.40
505.705.525.52
546.115.535.53
491.685.135.13
485.605.135.13
477.654.744.74
516.085.955.95
565.806.996.99
525.695.705.70
509.564.814.81
642.677.227.22
572.485.665.66
450.354.224.22
475.685.515.51
537.756.436.43
502.065.655.65
475.685.435.43
466.024.774.77
526.125.875.87
518.065.355.35
509.564.814.81
492.985.415.41
475.634.584.58
477.654.824.82
355.463.653.65
505.705.525.52
572.197.087.08
477.585.205.20
341.484.254.25
530.425.785.78
450.354.224.22
554.786.706.70
502.065.655.65
507.674.754.75
515.635.145.14
512.435.655.65
397.563.453.45
472.575.065.06
499.635.445.44
465.614.874.87
554.516.776.77
485.965.685.68
491.685.135.13
481.645.135.13
493.606.156.15
549.714.904.90
491.615.595.59
463.624.354.35
507.696.046.04
489.664.884.88
580.616.836.83
546.876.306.30
485.965.685.68
503.736.086.08
542.455.655.65
511.674.884.88
494.085.535.53
534.146.336.33
482.005.845.84
570.607.387.38
484.044.704.70
556.435.375.37
469.515.165.16
445.614.434.43
512.435.655.65
539.684.904.90
516.085.955.95
594.587.097.09
511.675.315.31
570.465.435.43
525.695.535.53
399.583.553.55
405.543.563.56
433.604.264.26
537.704.624.62
492.985.415.41
544.507.187.18
511.675.315.31
537.704.764.76
467.524.724.72
505.594.984.98
451.594.484.48
489.705.545.54
522.846.536.53
567.776.446.44
489.664.884.88
465.614.734.73
460.005.355.35
560.545.905.90
508.115.945.94
485.965.685.68
468.045.005.00
389.904.304.30
475.685.295.29
491.684.994.99
494.085.535.53
498.074.944.94
385.493.653.65
498.005.555.55
525.695.185.18
489.705.695.69
605.796.366.36
475.685.295.29
516.085.795.79
538.535.665.66
496.095.785.78
572.197.597.59
505.705.385.38
506.386.026.02
502.065.655.65
546.876.306.30
426.324.454.45
498.464.724.72
562.876.006.00
513.644.704.70
503.644.604.60
546.876.306.30
528.425.355.35
482.075.395.39
562.876.006.00
530.116.106.10
620.668.568.56
357.502.522.52
581.766.166.16
389.453.593.59
495.675.445.44
461.655.045.04
622.256.886.88
451.525.025.02
532.085.495.49
541.695.325.32
447.985.105.10
467.614.994.99
512.495.115.11
532.085.655.65
475.615.755.75
491.685.135.13