Basic Information
ID: ALA4421916
Type: Binding
Description: Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as reduction in geranylgeranylation of RhoA incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay relative to control
Organism: Rattus norvegicus
Activity Charts
Bioactivity
Activity Types for Assay ALA4421916
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 465.62 | 4.40 | 4.40 |
| 582.63 | 7.05 | 7.05 |
| 624.71 | 8.23 | 8.23 |
| 604.59 | 6.54 | 6.54 |
| 502.42 | 6.19 | 6.19 |
| 468.40 | 5.47 | 5.47 |
| 462.01 | 5.30 | 5.30 |
| 389.45 | 3.67 | 3.67 |
| 580.58 | 5.03 | 5.03 |
| 611.74 | 6.75 | 6.75 |
| 417.50 | 4.31 | 4.31 |
| 650.02 | 7.15 | 7.15 |
| 433.96 | 4.82 | 4.82 |
| 738.93 | 7.37 | 7.37 |
| 645.02 | 5.40 | 5.40 |
| 622.25 | 6.88 | 6.88 |
| 698.01 | 6.86 | 6.86 |
| 357.86 | 3.08 | 3.08 |
| 399.94 | 4.25 | 4.25 |
| 432.97 | 4.22 | 4.22 |
| 669.46 | 6.60 | 6.60 |
| 546.87 | 6.30 | 6.30 |
| 488.44 | 6.10 | 6.10 |
| 568.60 | 6.66 | 6.66 |
| 533.27 | 5.93 | 5.93 |
| 434.39 | 4.90 | 4.90 |
| 567.29 | 6.64 | 6.64 |
| 611.74 | 6.75 | 6.75 |
| 757.93 | 6.88 | 6.88 |
| 714.47 | 7.37 | 7.37 |
| 678.02 | 6.75 | 6.75 |
| 426.32 | 4.45 | 4.45 |
| 551.77 | 7.17 | 7.17 |
| 636.00 | 7.07 | 7.07 |
| 550.83 | 6.13 | 6.13 |
| 468.40 | 5.47 | 5.47 |
| 523.27 | 6.47 | 6.47 |
| 608.22 | 6.57 | 6.57 |
| 434.54 | 4.31 | 4.31 |
| 391.88 | 3.79 | 3.79 |
| 448.97 | 4.24 | 4.24 |
| 572.62 | 7.60 | 7.60 |
| 522.84 | 6.53 | 6.53 |
| 723.91 | 6.68 | 6.68 |
| 614.59 | 6.12 | 6.12 |
| 463.00 | 4.41 | 4.41 |
| 567.29 | 6.64 | 6.64 |
| 639.21 | 5.65 | 5.65 |
| 713.48 | 6.77 | 6.77 |
| 323.41 | 2.43 | 2.43 |
| 680.45 | 7.17 | 7.17 |
| 624.20 | 4.96 | 4.96 |
| 451.52 | 5.02 | 5.02 |
| 714.47 | 7.37 | 7.37 |
| 568.60 | 6.66 | 6.66 |
| 595.16 | 5.64 | 5.64 |
| 476.04 | 5.85 | 5.85 |
| 670.01 | 7.26 | 7.26 |
| 498.83 | 5.27 | 5.27 |
| 679.46 | 6.58 | 6.58 |
| 679.46 | 6.06 | 6.06 |
| 501.44 | 5.59 | 5.59 |
| 629.61 | 6.81 | 6.81 |
| 694.48 | 7.26 | 7.26 |
| 680.45 | 7.17 | 7.17 |
| 656.19 | 6.86 | 6.86 |
| 581.13 | 5.55 | 5.55 |
| 679.46 | 6.58 | 6.58 |
| 614.60 | 5.60 | 5.60 |
| 625.19 | 5.56 | 5.56 |
| 622.23 | 5.97 | 5.97 |
| 419.97 | 4.73 | 4.73 |
| 642.67 | 7.22 | 7.22 |
| 611.74 | 6.75 | 6.75 |
| 557.28 | 7.19 | 7.19 |
| 591.32 | 6.41 | 6.41 |
| 713.48 | 6.77 | 6.77 |
| 580.15 | 4.95 | 4.95 |
| 546.13 | 4.75 | 4.75 |
| 694.48 | 7.26 | 7.26 |
| 758.92 | 7.48 | 7.48 |
| 724.90 | 7.28 | 7.28 |
| 594.58 | 7.09 | 7.09 |
| 669.03 | 6.66 | 6.66 |
| 663.01 | 6.06 | 6.06 |
| 663.99 | 6.66 | 6.66 |
| 550.83 | 6.13 | 6.13 |