Basic Information
ID: ALA4422004
Type: Binding
Description: Binding affinity to nuclear export signal of topoisomerase 2alpha in human U266 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4422004
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 310.22 | 1.46 | 1.46 |
| 340.38 | 4.08 | 4.08 |
| 497.52 | 2.80 | 2.80 |
| 204.24 | -0.99 | -0.99 |
| 334.66 | 2.66 | 2.66 |
| 240.31 | 1.59 | 1.59 |
| 314.43 | 0.20 | 0.20 |