Basic Information
ID: ALA4422402
Type: Binding
Description: Selectivity index, ratio of IC50 for inhibition of human CYP3A4 assessed as reduction in enzyme-mediated testosterone 6-hydroxylation to IC50 for inhibition of human CYP2A6 assessed as reduction in enzyme-mediated coumarin 7-hydroxylation
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4422402
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 162.24 | 1.85 | 1.85 |
| 148.21 | 1.51 | 1.51 |
| 133.19 | 1.50 | 1.50 |
| 146.19 | 0.65 | 0.65 |
| 190.63 | 2.80 | 2.80 |
| 146.19 | 1.66 | 1.66 |
| 206.25 | 3.30 | 3.30 |
| 206.23 | 2.72 | 2.72 |
| 161.23 | 2.81 | 2.81 |
| 145.16 | 1.47 | 1.47 |
| 159.19 | 1.78 | 1.78 |
| 179.22 | 2.95 | 2.95 |
| 191.25 | 2.82 | 2.82 |
| 204.25 | 2.62 | 2.62 |
| 188.19 | 2.15 | 2.15 |
| 188.19 | 2.15 | 2.15 |
| 240.13 | 3.57 | 3.57 |
| 175.26 | 3.12 | 3.12 |
| 193.25 | 3.26 | 3.26 |
| 205.28 | 3.13 | 3.13 |
| 173.17 | 2.15 | 2.15 |
| 156.19 | 2.14 | 2.14 |
| 170.22 | 2.45 | 2.45 |
| 170.22 | 2.45 | 2.45 |
| 170.22 | 2.45 | 2.45 |
| 170.22 | 2.45 | 2.45 |
| 157.18 | 1.54 | 1.54 |
| 157.18 | 1.54 | 1.54 |
| 156.19 | 2.14 | 2.14 |
| 147.14 | 0.26 | 0.26 |
| 147.14 | 0.06 | 0.06 |
| 173.22 | 1.97 | 1.97 |
| 235.29 | 2.99 | 2.99 |
| 159.19 | 1.58 | 1.58 |
| 145.16 | 1.27 | 1.27 |
| 189.24 | 2.62 | 2.62 |
| 203.27 | 3.01 | 3.01 |
| 190.27 | 2.27 | 2.27 |
| 363.51 | 5.22 | 5.22 |
| 174.20 | 1.80 | 1.80 |
| 191.25 | 2.30 | 2.30 |
| 175.19 | 1.83 | 1.83 |
| 132.17 | 0.39 | 0.39 |
| 160.22 | 0.99 | 0.99 |
| 488.55 | 6.85 | 6.85 |
| 184.24 | 2.21 | 2.21 |
| 189.28 | 3.43 | 3.43 |
| 204.30 | 2.53 | 2.53 |
| 161.23 | 2.81 | 2.81 |
| 162.22 | 2.21 | 2.21 |
| 175.26 | 3.12 | 3.12 |
| 193.25 | 3.26 | 3.26 |
| 188.23 | 2.06 | 2.06 |
| 218.32 | 2.87 | 2.87 |
| 202.26 | 2.40 | 2.40 |
| 159.19 | 1.48 | 1.48 |
| 205.28 | 3.13 | 3.13 |
| 254.15 | 3.88 | 3.88 |
| 233.29 | 3.12 | 3.12 |
| 191.25 | 2.77 | 2.77 |
| 205.28 | 3.20 | 3.20 |
| 173.21 | 2.41 | 2.41 |
| 189.28 | 2.87 | 2.87 |
| 174.27 | 3.72 | 3.72 |
| 160.24 | 3.42 | 3.42 |
| 176.24 | 2.51 | 2.51 |
| 145.17 | 1.47 | 1.47 |
| 136.20 | 0.97 | 0.97 |
| 174.21 | 0.93 | 0.93 |
| 175.19 | 1.20 | 1.20 |
| 176.22 | 1.37 | 1.37 |
| 160.22 | 2.05 | 2.05 |
| 146.15 | 0.66 | 0.66 |
| 158.20 | 2.09 | 2.09 |
| 162.24 | 1.90 | 1.90 |
| 237.31 | 2.34 | 2.34 |
| 161.23 | 1.63 | 1.63 |
| 178.24 | 1.86 | 1.86 |
| 162.19 | 1.03 | 1.03 |
| 175.26 | 3.12 | 3.12 |
| 271.41 | 5.16 | 5.16 |
| 176.24 | 2.39 | 2.39 |
| 134.18 | 0.90 | 0.90 |
| 178.24 | 1.26 | 1.26 |
| 242.12 | 2.70 | 2.70 |
| 233.29 | 2.91 | 2.91 |
| 201.29 | 3.62 | 3.62 |
| 204.30 | 3.01 | 3.01 |
| 185.25 | 2.79 | 2.79 |
| 177.25 | 2.71 | 2.71 |
| 199.28 | 2.85 | 2.85 |
| 160.22 | 1.67 | 1.67 |
| 202.26 | 2.23 | 2.23 |
| 243.36 | 4.54 | 4.54 |
| 203.31 | 3.74 | 3.74 |
| 190.27 | 2.70 | 2.70 |
| 192.26 | 2.17 | 2.17 |
| 185.25 | 2.54 | 2.54 |
| 179.22 | 1.29 | 1.29 |
| 205.28 | 2.61 | 2.61 |
| 223.73 | 4.08 | 4.08 |
| 176.26 | 2.24 | 2.24 |
| 233.27 | 3.21 | 3.21 |
| 178.24 | 1.26 | 1.26 |
| 188.19 | 2.15 | 2.15 |
| 372.52 | 5.95 | 5.95 |