Basic Information
ID: ALA4422582
Type: Binding
Description: Inhibition of SARM1 in CD1 mouse DRG cells assessed as inhibition of axon degeneration by measuring reduction in NAD+ consumption rate at 5 uM added 30 mins prior to D4-Nam addition and measured 4 hrs post D4-Nam addition by LC-MS/MS analysis
Format: BAO_0000219
Organism: Mus musculus
Strain: CD1
Target: NAD(+) hydrolase SARM1(ALA4523348)
Document: ALA4421736
Inhibition of SARM1 in CD1 mouse DRG cells assessed as inhibition of axon degeneration by measuring reduction in NAD+ consumption rate at 5 uM added 30 mins prior to D4-Nam addition and measured 4 hrs post D4-Nam addition by LC-MS/MS analysis: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4422582
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 450.62 | 6.70 | 6.70 |
| 290.26 | 1.92 | 1.92 |
| 267.28 | 2.93 | 2.93 |
| 291.31 | 3.28 | 3.28 |
| 275.31 | 3.58 | 3.58 |
| 272.29 | 1.65 | 1.65 |
| 342.42 | 2.71 | 2.71 |
| 246.26 | 2.79 | 2.79 |
| 236.27 | 2.94 | 2.94 |
| 266.26 | 1.59 | 1.59 |
| 275.31 | 3.58 | 3.58 |
| 303.39 | 1.45 | 1.45 |
| 303.30 | 2.61 | 2.61 |
| 262.35 | 2.37 | 2.37 |
| 261.28 | 3.27 | 3.27 |
| 541.74 | 6.74 | 6.74 |
| 332.49 | 3.94 | 3.94 |
| 399.21 | 1.23 | 1.23 |
| 322.25 | 1.96 | 1.96 |
| 352.71 | 3.16 | 3.16 |