Basic Information
ID: ALA4422881
Type: Binding
Description: Ratio of IC50 for inhibition of recombinant full length human GST-tagged SHP2 PTP domain using pNPP as substrate pre-incubated for 15 mins before pNPP substrate addition and measured after 15 mins to IC50 for inhibition of wild type recombinant human SHP2 using H-Glu-Phe-pTyr-Ala-Glu-Val-Gly-Arg-Ser-Pro-Pro-Asp-Pro-Ala-Lys as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by Malachite Green-reagent based assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Protein-tyrosine phosphatase 2C(ALA3864)
Document: ALA4422612
Ratio of IC50 for inhibition of recombinant full length human GST-tagged SHP2 PTP domain using pNPP as substrate pre-incubated for 15 mins before pNPP substrate addition and measured after 15 mins to IC50 for inhibition of wild type recombinant human SHP2 using H-Glu-Phe-pTyr-Ala-Glu-Val-Gly-Arg-Ser-Pro-Pro-Asp-Pro-Ala-Lys as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by Malachite Green-reagent based assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4422881
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 564.47 | 6.38 | 6.38 |