Basic Information
ID: ALA4423436
Type: Functional
Description: Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preincubated for 142 secs followed by agonist addition and measured after 120 secs by Fluo-4-AM-dye based fluorescence assay
Organism: Rattus norvegicus
Activity Charts
Bioactivity
Activity Types for Assay ALA4423436
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 408.34 | 3.44 | 3.44 |
| 344.80 | 3.55 | 3.55 |
| 484.43 | 5.01 | 5.01 |
| 448.40 | 4.22 | 4.22 |
| 462.43 | 4.61 | 4.61 |
| 422.41 | 4.23 | 4.23 |
| 390.85 | 4.12 | 4.12 |
| 394.35 | 3.80 | 3.80 |
| 464.44 | 4.85 | 4.85 |
| 442.37 | 3.81 | 3.81 |
| 440.40 | 4.37 | 4.37 |
| 476.46 | 5.00 | 5.00 |
| 372.86 | 3.98 | 3.98 |
| 476.33 | 4.37 | 4.37 |
| 450.42 | 4.46 | 4.46 |
| 392.82 | 3.57 | 3.57 |