Basic Information
ID: ALA4425572
Type: Functional
Description: Reduction in ADAMTS-4/ADAMTS-5 mediated aggrecan cleavage products in Lewis rat model of MIA assessed as aggrecanase-cleaved fragments at 10 mg/kg, po bid administered post 3 days MIA induction measured after 4 hrs of last dosage on day 7 by NITEGE sandwich ELISA
Organism: Rattus norvegicus
Strain: Lewis
Activity Charts
Bioactivity
Activity Types for Assay ALA4425572
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 390.81 | 2.01 | 2.01 |
| 421.34 | 1.65 | 1.65 |
| 435.36 | 1.96 | 1.96 |
| 435.36 | 2.13 | 2.13 |