Basic Information
ID: ALA4425651
Type: Functional
Description: Reduction in ADAMTS-4/ADAMTS-5 mediated aggrecan cleavage products in Lewis rat model of MIA assessed as aggrecanase-cleaved fragments at 30 mg/kg, po qd administered post 3 days MIA induction measured after 4 hrs of last dosage on day 7 by NITEGE sandwich ELISA
Organism: Rattus norvegicus
Strain: Lewis
Activity Charts
Bioactivity
Activity Types for Assay ALA4425651
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 472.92 | 2.47 | 2.47 |
| 381.31 | 2.17 | 2.17 |