Basic Information
ID: ALA4426799
Type: ADME
Description: Mechanism based time dependent inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline production using 7-benzyloxyquinoline as substrate and NADPH measured every 3 mins for 15 mins by fluorimetry
Format: BAO_0000357
Organism: Homo sapiens
Target: Cytochrome P450 3A4(ALA340)
Document: ALA4425133
Mechanism based time dependent inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline production using 7-benzyloxyquinoline as substrate and NADPH measured every 3 mins for 15 mins by fluorimetry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4426799
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 456.56 | 2.34 | 2.34 |
| 568.73 | 4.44 | 4.44 |
| 540.68 | 3.66 | 3.66 |
| 550.65 | 4.15 | 4.15 |
| 500.61 | 2.74 | 2.74 |
| 553.72 | 4.08 | 4.08 |
| 528.66 | 3.52 | 3.52 |
| 566.64 | 4.27 | 4.27 |
| 511.64 | 2.91 | 2.91 |
| 550.65 | 4.15 | 4.15 |
| 548.65 | 4.13 | 4.13 |
| 554.70 | 4.05 | 4.05 |
| 555.69 | 2.93 | 2.93 |