Basic Information
ID: ALA4427853
Type: Binding
Description: Inhibition of recombinant N-terminal GST-tagged full-length IRAK4 in human THP1-XBlue cells assessed as decrease in NF-kappaB level preincubated for 1 hr followed by stimulation with LPS for 4 to 5 hrs measured after 30 mins by spectrophotometric analysis
Format: BAO_0000219
Organism: Homo sapiens
Target: Interleukin-1 receptor-associated kinase 4(ALA3778)
Document: ALA4425185
Inhibition of recombinant N-terminal GST-tagged full-length IRAK4 in human THP1-XBlue cells assessed as decrease in NF-kappaB level preincubated for 1 hr followed by stimulation with LPS for 4 to 5 hrs measured after 30 mins by spectrophotometric analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4427853
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 325.33 | 0.57 | 0.57 |
| 460.54 | 1.98 | 1.98 |
| 362.39 | 2.11 | 2.11 |
| 337.34 | 0.81 | 0.81 |
| 369.39 | -0.78 | -0.78 |
| 419.37 | 2.20 | 2.20 |
| 390.45 | 2.66 | 2.66 |
| 504.60 | 1.70 | 1.70 |
| 391.44 | 2.05 | 2.05 |
| 356.77 | 1.88 | 1.88 |