Basic Information
ID: ALA4430592
Type: Binding
Description: Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 20 nM GnRH-induced NFAT activation pre-incubated for 1 hr before GnRH stimulation and measured after 6 hrs by luciferase reporter gene assay
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4430592
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 495.50 | 4.16 | 4.16 |
| 590.63 | 3.58 | 3.58 |
| 652.72 | 5.16 | 5.16 |
| 610.66 | 4.25 | 4.25 |
| 640.64 | 4.46 | 4.46 |
| 664.63 | 4.96 | 4.96 |
| 602.66 | 4.00 | 4.00 |
| 658.63 | 4.59 | 4.59 |
| 620.65 | 4.42 | 4.42 |
| 679.64 | 5.45 | 5.45 |
| 637.64 | 4.08 | 4.08 |
| 585.60 | 4.14 | 4.14 |
| 620.65 | 4.42 | 4.42 |
| 597.62 | 3.34 | 3.34 |
| 641.71 | 5.44 | 5.44 |
| 739.69 | 5.65 | 5.65 |
| 620.05 | 4.79 | 4.79 |
| 612.63 | 3.24 | 3.24 |
| 662.69 | 5.20 | 5.20 |
| 664.63 | 4.96 | 4.96 |
| 614.62 | 4.08 | 4.08 |
| 638.67 | 3.65 | 3.65 |
| 610.66 | 4.25 | 4.25 |
| 667.63 | 5.47 | 5.47 |
| 653.68 | 4.33 | 4.33 |
| 710.73 | 3.75 | 3.75 |
| 653.60 | 5.16 | 5.16 |
| 620.65 | 4.42 | 4.42 |
| 651.73 | 5.76 | 5.76 |
| 599.63 | 4.45 | 4.45 |
| 602.66 | 4.00 | 4.00 |
| 614.62 | 4.08 | 4.08 |
| 726.73 | 4.95 | 4.95 |
| 597.62 | 3.34 | 3.34 |
| 613.61 | 3.50 | 3.50 |
| 635.66 | 5.29 | 5.29 |
| 610.66 | 4.25 | 4.25 |
| 652.69 | 3.91 | 3.91 |
| 664.63 | 4.96 | 4.96 |
| 673.73 | 3.95 | 3.95 |
| 601.67 | 4.61 | 4.61 |
| 637.68 | 4.75 | 4.75 |
| 664.63 | 4.96 | 4.96 |
| 610.61 | 4.01 | 4.01 |
| 631.07 | 4.60 | 4.60 |
| 638.64 | 4.56 | 4.56 |
| 586.59 | 3.53 | 3.53 |
| 638.64 | 4.56 | 4.56 |
| 724.76 | 4.14 | 4.14 |
| 612.63 | 3.24 | 3.24 |
| 631.62 | 4.83 | 4.83 |
| 636.65 | 4.69 | 4.69 |
| 628.63 | 3.24 | 3.24 |
| 669.67 | 5.63 | 5.63 |
| 653.60 | 5.16 | 5.16 |
| 643.64 | 3.93 | 3.93 |
| 749.73 | 6.06 | 6.06 |
| 663.64 | 5.57 | 5.57 |
| 775.66 | 5.36 | 5.36 |
| 639.65 | 4.25 | 4.25 |
| 602.66 | 4.00 | 4.00 |
| 613.63 | 4.69 | 4.69 |
| 775.74 | 5.07 | 5.07 |
| 655.58 | 3.95 | 3.95 |
| 666.72 | 4.30 | 4.30 |
| 656.64 | 4.16 | 4.16 |
| 631.07 | 4.60 | 4.60 |
| 657.73 | 4.28 | 4.28 |
| 646.69 | 5.10 | 5.10 |
| 656.66 | 3.78 | 3.78 |
| 613.63 | 4.69 | 4.69 |
| 653.68 | 4.33 | 4.33 |
| 714.67 | 3.92 | 3.92 |
| 596.63 | 3.94 | 3.94 |
| 742.73 | 4.70 | 4.70 |
| 585.60 | 4.14 | 4.14 |
| 586.59 | 3.53 | 3.53 |
| 696.70 | 3.36 | 3.36 |
| 803.71 | 6.40 | 6.40 |
| 715.72 | 5.19 | 5.19 |