Basic Information
ID: ALA4431936
Type: Binding
Description: Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY1222 for 30 to 60 mins followed by addition of DiFMUP measured after 30 mins by fluorescence analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4431936
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 452.60 | 2.81 | 2.81 |
| 503.43 | 4.00 | 4.00 |
| 325.28 | 1.85 | 1.85 |
| 557.61 | 6.20 | 6.20 |
| 637.46 | 6.16 | 6.16 |
| 352.27 | 3.35 | 3.35 |
| 352.27 | 3.35 | 3.35 |
| 338.24 | 2.96 | 2.96 |
| 352.27 | 3.22 | 3.22 |
| 352.27 | 3.22 | 3.22 |
| 353.26 | 2.75 | 2.75 |
| 311.43 | 2.53 | 2.53 |
| 366.30 | 3.81 | 3.81 |
| 317.82 | 2.57 | 2.57 |
| 337.25 | 3.77 | 3.77 |
| 366.30 | 3.56 | 3.56 |