Basic Information
ID: ALA4432803
Type: Binding
Description: Inhibition of human DOTL1 (2 to 416 residues)-mediated methylation of nucleosome preincubated for 30 mins followed by addition of S-[methyl-3H-] adenosyl-L-methionine and nucleosome measured after 180 mins by scintillation proximity assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Histone-lysine N-methyltransferase, H3 lysine-79 specific(ALA1795117)
Document: ALA4431372
Inhibition of human DOTL1 (2 to 416 residues)-mediated methylation of nucleosome preincubated for 30 mins followed by addition of S-[methyl-3H-] adenosyl-L-methionine and nucleosome measured after 180 mins by scintillation proximity assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4432803
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 297.14 | 2.91 | 2.91 |
| 303.19 | 5.31 | 5.31 |
| 434.33 | 5.41 | 5.41 |
| 435.31 | 4.83 | 4.83 |
| 302.16 | 4.77 | 4.77 |
| 483.36 | 3.58 | 3.58 |
| 343.22 | 4.29 | 4.29 |
| 450.33 | 4.53 | 4.53 |
| 333.22 | 5.32 | 5.32 |
| 374.23 | 4.57 | 4.57 |