Basic Information
ID: ALA4432973
Type: Binding
Description: Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of recombinant C-terminal FLAG-tagged LEDGF/p75-induced integration of viral 32-mer blunt-ended U5 DNA into pBR322 DNA preincubated with enzyme for 30 mins followed by viral and target DNA addition and subsequent addition of LEDGF/p75 after 5 mins measured after 90 mins by HTRF assay
Format: BAO_0000219
Organism: Human immunodeficiency virus 1
Target: Human immunodeficiency virus type 1 integrase(ALA3471)
Document: ALA4431384
Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of recombinant C-terminal FLAG-tagged LEDGF/p75-induced integration of viral 32-mer blunt-ended U5 DNA into pBR322 DNA preincubated with enzyme for 30 mins followed by viral and target DNA addition and subsequent addition of LEDGF/p75 after 5 mins measured after 90 mins by HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4432973
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 420.69 | 5.40 | 5.40 |
| 415.47 | 5.11 | 5.11 |
| 373.43 | 4.71 | 4.71 |
| 351.45 | 4.66 | 4.66 |
| 367.45 | 4.89 | 4.89 |
| 389.43 | 4.79 | 4.79 |
| 465.53 | 6.31 | 6.31 |
| 359.40 | 4.79 | 4.79 |