Basic Information
ID: ALA4433405
Type: Binding
Description: Inhibition of human BACE1 using as 7-Methoxycoumarin-4-acetyl-[Asn670, Leu671]-Amyloid beta/A4 precursor protein 770 fragment 667-676-(2,4-dinitrophenyl) Lys-Arg-Arg amide trifluoroacetate salt as substrate incubated for 2 hrs by FRET based florescence assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Beta-secretase 1(ALA4822)
Document: ALA4433202
Inhibition of human BACE1 using as 7-Methoxycoumarin-4-acetyl-[Asn670, Leu671]-Amyloid beta/A4 precursor protein 770 fragment 667-676-(2,4-dinitrophenyl) Lys-Arg-Arg amide trifluoroacetate salt as substrate incubated for 2 hrs by FRET based florescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4433405
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 379.50 | 4.36 | 4.36 |
| 314.86 | 4.09 | 4.09 |
| 298.41 | 3.58 | 3.58 |
| 349.30 | 4.75 | 4.75 |
| 340.47 | 3.46 | 3.46 |
| 368.48 | 3.80 | 3.80 |
| 325.41 | 3.35 | 3.35 |
| 312.41 | 2.85 | 2.85 |
| 316.39 | 3.72 | 3.72 |
| 338.45 | 3.79 | 3.79 |
| 294.44 | 3.75 | 3.75 |
| 296.41 | 3.15 | 3.15 |
| 362.39 | 4.67 | 4.67 |
| 323.40 | 3.68 | 3.68 |
| 280.42 | 3.44 | 3.44 |
| 294.40 | 3.48 | 3.48 |
| 294.44 | 3.75 | 3.75 |
| 294.40 | 3.48 | 3.48 |
| 296.39 | 3.91 | 3.91 |
| 312.84 | 4.42 | 4.42 |
| 278.40 | 3.77 | 3.77 |
| 310.40 | 3.18 | 3.18 |
| 296.41 | 3.15 | 3.15 |
| 292.43 | 4.08 | 4.08 |
| 292.43 | 4.08 | 4.08 |
| 347.29 | 5.08 | 5.08 |
| 314.38 | 4.05 | 4.05 |
| 346.40 | 4.79 | 4.79 |
| 348.41 | 4.46 | 4.46 |
| 364.41 | 4.34 | 4.34 |
| 370.49 | 3.47 | 3.47 |