Basic Information
ID: ALA4433520
Type: Binding
Description: Inhibition of recombinant human N-terminal His6-tagged/SUMO-fused SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 assessed as reduction in deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by substrate addition and measured after 6 mins by UV-HPLC analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4433520
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 122.13 | 0.18 | 0.18 |
| 248.71 | 2.73 | 2.73 |
| 581.87 | 8.71 | 8.71 |
| 500.67 | 4.45 | 4.45 |
| 554.80 | 6.70 | 6.70 |
| 526.75 | 5.92 | 5.92 |
| 598.85 | 7.18 | 7.18 |
| 582.86 | 7.48 | 7.48 |
| 542.75 | 5.62 | 5.62 |
| 472.61 | 3.67 | 3.67 |
| 498.69 | 5.13 | 5.13 |
| 512.72 | 5.52 | 5.52 |
| 444.56 | 2.89 | 2.89 |
| 570.80 | 6.40 | 6.40 |