Basic Information
ID: ALA4433723
Type: Binding
Description: Antagonist activity at human FXR transfected in HepG2 cells assessed as inhibition of CDCA-induced receptor transactivation at 10 uM by luciferase reporter assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HepG2
Target: Bile acid receptor FXR(ALA2047)
Document: ALA4433214
Antagonist activity at human FXR transfected in HepG2 cells assessed as inhibition of CDCA-induced receptor transactivation at 10 uM by luciferase reporter assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4433723
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 243.31 | 2.13 | 2.13 |
| 365.43 | 4.28 | 4.28 |
| 229.28 | 2.20 | 2.20 |
| 351.45 | 3.84 | 3.84 |
| 265.32 | 3.31 | 3.31 |
| 365.48 | 4.23 | 4.23 |
| 305.38 | 3.87 | 3.87 |
| 337.42 | 3.80 | 3.80 |
| 379.46 | 4.32 | 4.32 |
| 337.38 | 3.50 | 3.50 |
| 279.34 | 3.36 | 3.36 |
| 311.31 | 3.15 | 3.15 |
| 351.45 | 4.19 | 4.19 |
| 351.41 | 3.54 | 3.54 |
| 279.34 | 3.70 | 3.70 |
| 297.28 | 3.22 | 3.22 |
| 337.42 | 3.80 | 3.80 |
| 365.48 | 4.58 | 4.58 |
| 379.46 | 4.67 | 4.67 |
| 351.41 | 3.89 | 3.89 |
| 323.40 | 3.41 | 3.41 |
| 337.42 | 3.45 | 3.45 |
| 365.43 | 3.93 | 3.93 |
| 351.45 | 4.19 | 4.19 |
| 365.43 | 4.28 | 4.28 |
| 351.41 | 3.89 | 3.89 |