Basic Information
ID: ALA4476912
Type: Binding
Description: Inhibition of human c-Myc assessed as reduction in c-Myc/Max/Ebox DNA complex formation using pre-formed complex of c-Myc and biotinylated DNA containing single Ebox-sequence followed by compound addition and further addition of his6-tagged c-Max and incubated for 2 hrs by AlphaScreen assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4476912
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 241.29 | 3.75 | 3.75 |
| 231.25 | 2.50 | 2.50 |
| 215.25 | 2.79 | 2.79 |
| 215.25 | 2.79 | 2.79 |
| 249.70 | 3.45 | 3.45 |
| 249.70 | 3.45 | 3.45 |
| 269.30 | 3.87 | 3.87 |
| 217.22 | 1.97 | 1.97 |
| 203.20 | 1.88 | 1.88 |
| 245.28 | 2.59 | 2.59 |
| 272.30 | 2.01 | 2.01 |
| 215.25 | 2.79 | 2.79 |
| 293.32 | 3.86 | 3.86 |
| 294.15 | 3.55 | 3.55 |
| 379.41 | 4.04 | 4.04 |
| 382.42 | 4.73 | 4.73 |
| 331.37 | 4.36 | 4.36 |
| 287.32 | 4.48 | 4.48 |
| 229.28 | 3.10 | 3.10 |
| 269.34 | 3.75 | 3.75 |
| 231.25 | 2.50 | 2.50 |
| 231.25 | 2.50 | 2.50 |
| 447.49 | 3.45 | 3.45 |
| 293.35 | 1.18 | 1.18 |
| 409.44 | 4.05 | 4.05 |
| 334.09 | 3.96 | 3.96 |
| 418.43 | 4.18 | 4.18 |
| 276.34 | 2.72 | 2.72 |
| 273.29 | 1.40 | 1.40 |
| 523.61 | 3.50 | 3.50 |
| 416.52 | 5.12 | 5.12 |
| 423.43 | 2.26 | 2.26 |
| 352.39 | 2.49 | 2.49 |
| 241.29 | 3.19 | 3.19 |
| 384.48 | 1.77 | 1.77 |
| 367.36 | 1.88 | 1.88 |
| 461.52 | 3.40 | 3.40 |
| 259.26 | 2.49 | 2.49 |
| 331.42 | 5.03 | 5.03 |
| 351.37 | 2.28 | 2.28 |
| 394.43 | 3.18 | 3.18 |
| 292.34 | 1.12 | 1.12 |
| 411.44 | 3.32 | 3.32 |
| 549.54 | 3.21 | 3.21 |
| 341.36 | 2.96 | 2.96 |
| 441.39 | 3.53 | 3.53 |
| 432.52 | 4.82 | 4.82 |
| 446.50 | 4.51 | 4.51 |
| 265.31 | 3.95 | 3.95 |
| 274.28 | 1.86 | 1.86 |
| 287.32 | 1.48 | 1.48 |
| 321.76 | 3.42 | 3.42 |
| 303.31 | 2.48 | 2.48 |
| 276.34 | 2.58 | 2.58 |
| 243.31 | 3.41 | 3.41 |
| 336.37 | 1.48 | 1.48 |
| 497.40 | 5.59 | 5.59 |
| 447.50 | 2.49 | 2.49 |
| 415.37 | 3.97 | 3.97 |
| 461.52 | 3.40 | 3.40 |
| 402.49 | 4.81 | 4.81 |
| 387.44 | 3.05 | 3.05 |
| 316.39 | 1.96 | 1.96 |
| 423.43 | 2.36 | 2.36 |
| 422.44 | 2.46 | 2.46 |
| 409.40 | 2.67 | 2.67 |
| 361.40 | 3.56 | 3.56 |
| 265.31 | 3.95 | 3.95 |
| 494.50 | 2.44 | 2.44 |
| 447.49 | 3.45 | 3.45 |
| 481.46 | 2.65 | 2.65 |
| 406.44 | 3.46 | 3.46 |
| 523.61 | 3.50 | 3.50 |
| 405.22 | ||
| 480.50 | 3.20 | 3.20 |
| 341.36 | 2.96 | 2.96 |
| 260.25 | 2.70 | 2.70 |
| 363.38 | 2.35 | 2.35 |
| 566.70 | 4.51 | 4.51 |
| 273.29 | 2.72 | 2.72 |
| 441.47 | 2.80 | 2.80 |
| 401.42 | 4.04 | 4.04 |
| 413.44 | 3.50 | 3.50 |
| 239.28 | 2.27 | 2.27 |
| 421.45 | 3.57 | 3.57 |
| 277.32 | 4.15 | 4.15 |
| 425.45 | 3.91 | 3.91 |
| 305.38 | 4.63 | 4.63 |
| 260.25 | 2.70 | 2.70 |
| 413.44 | 3.50 | 3.50 |
| 216.24 | 2.19 | 2.19 |
| 450.47 | 2.92 | 2.92 |
| 460.53 | 4.44 | 4.44 |
| 447.39 | 4.71 | 4.71 |
| 418.43 | 4.18 | 4.18 |
| 279.72 | 3.45 | 3.45 |
| 279.29 | 1.20 | 1.20 |
| 407.38 | 3.63 | 3.63 |
| 403.39 | 4.21 | 4.21 |
| 677.76 | 9.25 | 9.25 |
| 226.28 | 3.67 | 3.67 |
| 503.49 | 2.38 | 2.38 |
| 214.27 | 2.19 | 2.19 |
| 354.43 | 3.21 | 3.21 |
| 229.28 | 2.88 | 2.88 |
| 259.26 | 2.15 | 2.15 |
| 356.40 | 3.46 | 3.46 |
| 461.52 | 3.40 | 3.40 |
| 418.45 | 3.69 | 3.69 |
| 431.43 | 2.40 | 2.40 |
| 328.37 | 2.26 | 2.26 |
| 404.47 | 3.62 | 3.62 |
| 404.47 | 3.15 | 3.15 |
| 395.39 | 3.40 | 3.40 |
| 600.72 | 2.49 | 2.49 |
| 412.45 | 4.10 | 4.10 |
| 292.36 | 1.78 | 1.78 |
| 385.44 | 4.11 | 4.11 |
| 259.30 | 3.11 | 3.11 |
| 216.24 | 2.19 | 2.19 |
| 421.41 | 2.57 | 2.57 |
| 423.40 | 3.39 | 3.39 |
| 318.40 | 2.32 | 2.32 |
| 432.48 | 2.79 | 2.79 |
| 457.49 | 4.28 | 4.28 |
| 447.49 | 3.45 | 3.45 |
| 371.44 | 2.09 | 2.09 |
| 318.42 | 3.75 | 3.75 |
| 446.51 | 3.39 | 3.39 |
| 377.40 | 3.26 | 3.26 |
| 404.47 | 3.39 | 3.39 |
| 432.48 | 3.38 | 3.38 |
| 304.39 | 3.50 | 3.50 |
| 436.94 | 5.47 | 5.47 |
| 432.52 | 4.82 | 4.82 |
| 275.30 | 2.81 | 2.81 |
| 297.35 | 3.64 | 3.64 |
| 403.39 | 4.21 | 4.21 |
| 251.31 | 2.34 | 2.34 |
| 202.21 | 1.88 | 1.88 |
| 287.31 | 2.77 | 2.77 |
| 351.37 | 2.28 | 2.28 |
| 308.18 | 3.86 | 3.86 |
| 416.52 | 5.12 | 5.12 |
| 417.51 | 4.06 | 4.06 |
| 444.49 | 4.42 | 4.42 |
| 305.38 | 4.77 | 4.77 |
| 405.41 | 3.25 | 3.25 |
| 378.43 | 3.78 | 3.78 |
| 447.42 | 3.60 | 3.60 |
| 297.35 | 3.64 | 3.64 |
| 371.26 | 2.55 | 2.55 |
| 458.31 | 4.81 | 4.81 |
| 395.37 | 2.85 | 2.85 |
| 362.39 | 2.95 | 2.95 |
| 216.24 | 2.19 | 2.19 |
| 444.49 | 4.42 | 4.42 |
| 249.70 | 3.45 | 3.45 |
| 231.25 | 2.50 | 2.50 |
| 269.22 | 3.50 | 3.50 |
| 446.50 | 4.51 | 4.51 |
| 220.27 | 1.14 | 1.14 |
| 485.50 | 3.48 | 3.48 |
| 393.44 | 4.43 | 4.43 |
| 347.37 | 2.79 | 2.79 |
| 361.40 | 3.56 | 3.56 |
| 397.38 | 3.83 | 3.83 |
| 446.50 | 4.51 | 4.51 |
| 259.26 | 2.49 | 2.49 |
| 452.51 | 4.54 | 4.54 |
| 443.46 | 3.77 | 3.77 |
| 412.45 | 4.10 | 4.10 |
| 432.27 | 3.65 | 3.65 |
| 501.50 | 2.72 | 2.72 |
| 229.28 | 2.72 | 2.72 |
| 418.49 | 4.52 | 4.52 |
| 319.36 | 4.02 | 4.02 |
| 434.49 | 3.40 | 3.40 |
| 429.44 | 2.74 | 2.74 |
| 419.48 | 3.46 | 3.46 |
| 272.30 | 2.75 | 2.75 |
| 385.51 | 2.60 | 2.60 |
| 405.41 | 3.25 | 3.25 |
| 378.43 | 3.78 | 3.78 |
| 439.48 | 4.01 | 4.01 |