Assay Report Card

Basic Information

ID: ALA4476934

Type: Binding

Description: Inhibition of C-terminal FLAG-6x-His epitope tagged and N-terminal human RAGE signal sequence tagged human BMP1 (23 to 721 amino acids) expressed in CHO-E1 cells pre-incubated for 10 mins before promyostatin peptide substrate addition and measured after 30 mins using 50 nM BMP1 by FRET based assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4476934

IC50

Total(146)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
401.46	2.79	2.79
445.47	2.49	2.49
517.58	3.67	3.67
431.49	2.80	2.80
445.52	3.19	3.19
553.55	2.77	2.77
429.52	3.57	3.57
445.47	2.49	2.49
517.58	3.67	3.67
632.67	2.63	2.63
553.55	2.77	2.77
632.67	2.63	2.63
702.66	2.91	2.91
619.76	3.41	3.41
588.61	2.23	2.23
531.61	3.60	3.60
499.49	3.74	3.74
431.49	2.80	2.80
515.61	3.94	3.94
531.56	2.90	2.90
662.65	1.69	1.69
513.59	3.69	3.69
461.58	3.91	3.91
602.64	2.54	2.54
515.61	3.94	3.94
433.55	2.92	2.92
444.53	2.86	2.86
567.59	4.15	4.15
546.58	2.14	2.14
449.48	2.94	2.94
581.60	4.08	4.08
501.58	3.75	3.75
588.61	2.23	2.23
489.53	2.98	2.98
435.48	2.85	2.85
507.52	3.36	3.36
508.60	2.04	2.04
455.52	2.68	2.68
602.64	2.62	2.62
487.55	3.58	3.58
567.58	3.65	3.65
531.61	3.60	3.60
489.53	2.98	2.98
505.54	3.34	3.34
459.50	2.42	2.42
463.46	2.63	2.63
474.51	2.67	2.67
487.55	3.20	3.20
487.60	4.36	4.36
591.61	2.77	2.77
459.54	3.58	3.58
475.50	2.50	2.50
533.58	3.38	3.38
646.69	2.56	2.56
467.47	3.40	3.40
574.63	2.79	2.79
535.57	3.81	3.81
513.57	2.25	2.25
477.49	2.72	2.72
481.45	2.77	2.77
432.48	2.20	2.20
525.50	2.08	2.08
662.65	1.69	1.69
503.55	2.98	2.98
632.67	2.63	2.63
446.46	2.70	2.70
646.69	3.02	3.02
426.47	2.67	2.67
461.52	2.81	2.81
459.50	2.58	2.58
481.50	3.44	3.44
517.54	2.97	2.97
426.47	2.67	2.67
688.78	3.89	3.89
582.55	2.14	2.14
632.67	2.58	2.58
646.69	3.02	3.02
485.46	3.69	3.69
547.56	2.73	2.73
459.50	2.58	2.58
574.68	3.49	3.49
566.55	2.44	2.44
702.80	4.28	4.28
583.53	1.84	1.84
459.50	2.58	2.58
666.68	2.68	2.68
710.64	3.20	3.20
419.39	1.08	1.08
557.58	2.12	2.12
432.48	2.20	2.20
461.52	2.81	2.81
463.46	2.63	2.63
587.57	2.83	2.83
514.62	3.27	3.27
531.61	1.88	1.88
536.61	2.01	2.01
610.60	2.84	2.84
417.46	2.50	2.50
567.60	3.43	3.43
674.75	3.20	3.20
473.53	3.27	3.27
666.68	2.64	2.64
487.56	2.67	2.67
513.59	3.69	3.69
489.53	2.89	2.89
495.47	2.25	2.25
610.60	2.84	2.84
481.44	1.60	1.60
461.47	2.20	2.20
588.61	2.23	2.23
445.47	2.49	2.49
533.58	3.38	3.38
489.57	3.68	3.68
563.56	2.44	2.44
494.57	1.70	1.70
716.74	3.83	3.83
413.47	2.79	2.79
531.61	4.06	4.06
480.54	1.44	1.44
431.49	2.16	2.16
459.50	2.80	2.80
475.50	2.50	2.50
633.56	2.77	2.77
449.51	3.24	3.24
447.56	3.52	3.52
458.52	2.15	2.15
473.53	2.98	2.98
475.50	2.50	2.50
460.49	2.07	2.07
459.50	2.80	2.80
517.58	1.49	1.49
588.61	2.18	2.18
492.55	1.59	1.59
580.58	2.75	2.75
702.66	2.96	2.96
432.48	2.20	2.20
567.58	3.43	3.43
503.55	3.28	3.28
559.66	2.66	2.66
620.70	1.42	1.42
637.63	3.98	3.98
479.47	2.32	2.32
509.50	2.91	2.91
632.67	2.58	2.58
632.67	2.63	2.63
455.52	2.68	2.68