Assay Report Card

Basic Information

ID: ALA4476935

Type: Binding

Description: Inhibition of recombinant human TLL1 I156V/N221S/V284A mutant expressed in CHOE1A cells pre-incubated for 10 mins before promyostatin peptide substrate addition and measured after 60 mins by FRET based assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4476935

IC50

Total(141)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
401.46	2.79	2.79
445.47	2.49	2.49
517.58	3.67	3.67
431.49	2.80	2.80
445.52	3.19	3.19
553.55	2.77	2.77
429.52	3.57	3.57
445.47	2.49	2.49
517.58	3.67	3.67
632.67	2.63	2.63
553.55	2.77	2.77
632.67	2.63	2.63
702.66	2.91	2.91
619.76	3.41	3.41
588.61	2.23	2.23
531.61	3.60	3.60
499.49	3.74	3.74
431.49	2.80	2.80
515.61	3.94	3.94
531.56	2.90	2.90
662.65	1.69	1.69
513.59	3.69	3.69
461.58	3.91	3.91
602.64	2.54	2.54
515.61	3.94	3.94
433.55	2.92	2.92
444.53	2.86	2.86
567.59	4.15	4.15
546.58	2.14	2.14
449.48	2.94	2.94
581.60	4.08	4.08
501.58	3.75	3.75
588.61	2.23	2.23
489.53	2.98	2.98
435.48	2.85	2.85
507.52	3.36	3.36
508.60	2.04	2.04
455.52	2.68	2.68
602.64	2.62	2.62
487.55	3.58	3.58
567.58	3.65	3.65
489.53	2.98	2.98
505.54	3.34	3.34
459.50	2.42	2.42
463.46	2.63	2.63
474.51	2.67	2.67
487.55	3.20	3.20
487.60	4.36	4.36
459.54	3.58	3.58
475.50	2.50	2.50
533.58	3.38	3.38
646.69	2.56	2.56
467.47	3.40	3.40
535.57	3.81	3.81
513.57	2.25	2.25
477.49	2.72	2.72
481.45	2.77	2.77
432.48	2.20	2.20
525.50	2.08	2.08
662.65	1.69	1.69
503.55	2.98	2.98
632.67	2.63	2.63
446.46	2.70	2.70
646.69	3.02	3.02
426.47	2.67	2.67
461.52	2.81	2.81
459.50	2.58	2.58
481.50	3.44	3.44
517.54	2.97	2.97
426.47	2.67	2.67
688.78	3.89	3.89
582.55	2.14	2.14
632.67	2.58	2.58
646.69	3.02	3.02
485.46	3.69	3.69
547.56	2.73	2.73
459.50	2.58	2.58
574.68	3.49	3.49
566.55	2.44	2.44
702.80	4.28	4.28
583.53	1.84	1.84
459.50	2.58	2.58
666.68	2.68	2.68
710.64	3.20	3.20
419.39	1.08	1.08
557.58	2.12	2.12
432.48	2.20	2.20
461.52	2.81	2.81
463.46	2.63	2.63
587.57	2.83	2.83
514.62	3.27	3.27
536.61	2.01	2.01
610.60	2.84	2.84
417.46	2.50	2.50
567.60	3.43	3.43
674.75	3.20	3.20
473.53	3.27	3.27
666.68	2.64	2.64
487.56	2.67	2.67
513.59	3.69	3.69
489.53	2.89	2.89
495.47	2.25	2.25
610.60	2.84	2.84
481.44	1.60	1.60
461.47	2.20	2.20
588.61	2.23	2.23
445.47	2.49	2.49
533.58	3.38	3.38
489.57	3.68	3.68
563.56	2.44	2.44
494.57	1.70	1.70
716.74	3.83	3.83
413.47	2.79	2.79
531.61	4.06	4.06
480.54	1.44	1.44
431.49	2.16	2.16
459.50	2.80	2.80
475.50	2.50	2.50
633.56	2.77	2.77
449.51	3.24	3.24
447.56	3.52	3.52
458.52	2.15	2.15
473.53	2.98	2.98
475.50	2.50	2.50
460.49	2.07	2.07
459.50	2.80	2.80
517.58	1.49	1.49
588.61	2.18	2.18
492.55	1.59	1.59
580.58	2.75	2.75
702.66	2.96	2.96
432.48	2.20	2.20
567.58	3.43	3.43
503.55	3.28	3.28
559.66	2.66	2.66
620.70	1.42	1.42
479.47	2.32	2.32
509.50	2.91	2.91
632.67	2.58	2.58
632.67	2.63	2.63
455.52	2.68	2.68