Basic Information
ID: ALA4477005
Type: Binding
Description: Inhibition of human c-Myc assessed as reduction in c-Myc/Max/Ebox DNA complex formation using pre-formed complex of c-Myc and biotinylated DNA containing single Ebox-sequence followed by compound addition and further addition of his6-tagged c-Max and incubated for 2 hrs by AlphaScreen assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4477005
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 469.64 | 3.50 | 3.50 |
| 442.61 | 2.74 | 2.74 |
| 409.97 | 2.70 | 2.70 |
| 418.55 | 2.03 | 2.03 |
| 452.01 | 3.28 | 3.28 |
| 358.49 | 3.97 | 3.97 |
| 484.68 | 4.26 | 4.26 |
| 413.57 | 3.39 | 3.39 |
| 444.59 | 1.32 | 1.32 |
| 454.58 | 3.48 | 3.48 |
| 316.41 | 2.98 | 2.98 |
| 469.66 | 4.55 | 4.55 |
| 441.54 | 2.57 | 2.57 |
| 484.65 | 3.00 | 3.00 |
| 538.14 | 5.93 | 5.93 |
| 455.61 | 3.26 | 3.26 |
| 456.60 | 2.17 | 2.17 |
| 429.57 | 2.51 | 2.51 |
| 372.52 | 4.32 | 4.32 |
| 436.55 | 5.64 | 5.64 |
| 439.61 | 3.88 | 3.88 |
| 386.55 | 4.71 | 4.71 |
| 443.55 | 2.41 | 2.41 |
| 358.49 | 3.97 | 3.97 |
| 489.62 | 4.37 | 4.37 |
| 455.61 | 2.97 | 2.97 |
| 443.64 | 4.51 | 4.51 |
| 468.65 | 3.22 | 3.22 |
| 482.68 | 3.37 | 3.37 |
| 443.60 | 3.12 | 3.12 |
| 440.60 | 2.30 | 2.30 |
| 465.60 | 4.72 | 4.72 |
| 489.67 | 4.76 | 4.76 |
| 481.59 | 3.88 | 3.88 |
| 443.60 | 2.90 | 2.90 |
| 455.63 | 2.54 | 2.54 |
| 518.54 | 3.25 | 3.25 |
| 346.44 | 2.26 | 2.26 |
| 457.63 | 3.46 | 3.46 |
| 399.55 | 3.15 | 3.15 |
| 442.61 | 2.59 | 2.59 |
| 457.67 | 4.90 | 4.90 |
| 505.09 | 4.64 | 4.64 |
| 459.60 | 2.94 | 2.94 |
| 469.60 | 3.22 | 3.22 |
| 442.61 | 2.64 | 2.64 |
| 474.48 | 3.39 | 3.39 |
| 455.61 | 3.12 | 3.12 |
| 413.57 | 3.54 | 3.54 |
| 372.52 | 4.32 | 4.32 |
| 344.47 | 3.33 | 3.33 |
| 344.47 | 3.58 | 3.58 |
| 503.66 | 4.39 | 4.39 |
| 482.68 | 3.61 | 3.61 |
| 415.59 | 3.78 | 3.78 |
| 468.65 | 2.98 | 2.98 |
| 344.47 | 3.19 | 3.19 |
| 429.62 | 4.34 | 4.34 |
| 502.67 | 5.01 | 5.01 |
| 427.60 | 3.78 | 3.78 |
| 372.52 | 4.14 | 4.14 |
| 445.57 | 1.74 | 1.74 |
| 386.55 | 4.71 | 4.71 |
| 330.44 | 3.02 | 3.02 |
| 503.66 | 4.62 | 4.62 |
| 439.57 | 2.91 | 2.91 |
| 427.60 | 3.78 | 3.78 |
| 497.69 | 4.43 | 4.43 |
| 428.59 | 2.47 | 2.47 |
| 459.64 | 3.65 | 3.65 |
| 387.53 | 2.96 | 2.96 |
| 429.57 | 2.51 | 2.51 |
| 358.49 | 3.97 | 3.97 |
| 481.65 | 3.61 | 3.61 |
| 455.57 | 2.88 | 2.88 |
| 344.47 | 3.37 | 3.37 |
| 465.61 | 3.18 | 3.18 |
| 465.61 | 3.11 | 3.11 |
| 512.71 | 3.14 | 3.14 |
| 459.64 | 3.39 | 3.39 |
| 454.63 | 2.83 | 2.83 |
| 454.63 | 2.74 | 2.74 |
| 469.66 | 4.55 | 4.55 |
| 489.63 | 3.83 | 3.83 |
| 497.62 | 3.86 | 3.86 |
| 530.59 | 4.90 | 4.90 |
| 414.56 | 1.96 | 1.96 |
| 439.61 | 3.74 | 3.74 |
| 471.65 | 3.90 | 3.90 |
| 471.65 | 3.90 | 3.90 |
| 429.62 | 4.34 | 4.34 |
| 443.60 | 2.90 | 2.90 |
| 454.63 | 2.73 | 2.73 |
| 431.59 | 2.94 | 2.94 |
| 454.63 | 2.83 | 2.83 |
| 386.55 | 4.71 | 4.71 |
| 470.65 | 3.95 | 3.95 |
| 457.63 | 3.50 | 3.50 |
| 394.95 | 3.64 | 3.64 |
| 435.52 | 3.35 | 3.35 |
| 457.63 | 3.41 | 3.41 |
| 429.62 | 4.17 | 4.17 |
| 439.57 | 2.91 | 2.91 |
| 495.63 | 2.82 | 2.82 |
| 542.17 | 5.69 | 5.69 |
| 415.59 | 3.78 | 3.78 |
| 372.52 | 4.14 | 4.14 |
| 453.62 | 2.99 | 2.99 |
| 453.60 | 3.47 | 3.47 |
| 440.60 | 2.28 | 2.28 |
| 483.62 | 3.69 | 3.69 |
| 464.62 | 3.62 | 3.62 |
| 482.64 | 3.91 | 3.91 |
| 441.63 | 4.17 | 4.17 |
| 440.60 | 2.20 | 2.20 |
| 454.58 | 3.48 | 3.48 |
| 510.69 | 3.58 | 3.58 |
| 441.63 | 4.27 | 4.27 |
| 489.65 | 2.12 | 2.12 |
| 482.68 | 3.37 | 3.37 |
| 481.65 | 3.50 | 3.50 |
| 471.66 | 1.89 | 1.89 |
| 520.71 | 5.14 | 5.14 |
| 480.62 | 2.51 | 2.51 |
| 454.58 | 3.48 | 3.48 |
| 372.52 | 4.14 | 4.14 |
| 427.60 | 3.78 | 3.78 |
| 416.58 | 3.78 | 3.78 |
| 443.60 | 3.07 | 3.07 |
| 373.51 | 2.61 | 2.61 |
| 358.49 | 3.97 | 3.97 |
| 386.55 | 4.71 | 4.71 |
| 456.64 | 3.03 | 3.03 |
| 500.65 | 2.27 | 2.27 |
| 415.59 | 3.78 | 3.78 |
| 429.62 | 4.17 | 4.17 |
| 502.54 | 4.01 | 4.01 |
| 482.68 | 3.54 | 3.54 |
| 453.60 | 2.92 | 2.92 |
| 482.68 | 3.54 | 3.54 |
| 440.60 | 2.30 | 2.30 |
| 330.44 | 3.02 | 3.02 |
| 417.56 | 2.63 | 2.63 |
| 374.50 | 2.61 | 2.61 |
| 386.55 | 4.71 | 4.71 |
| 456.60 | 2.21 | 2.21 |
| 429.57 | 2.77 | 2.77 |
| 469.64 | 3.36 | 3.36 |
| 440.55 | 3.17 | 3.17 |
| 469.64 | 3.51 | 3.51 |
| 358.49 | 3.97 | 3.97 |
| 456.62 | 3.64 | 3.64 |
| 380.44 | 3.96 | 3.96 |
| 386.55 | 4.71 | 4.71 |
| 438.58 | 3.24 | 3.24 |