Inhibition of human CH24H expressed in Freestyle-293 cells assessed as reduction in 24HC production at 1 uM incubated for 5 hrs using [14C]cholesterol...

Basic Information

ID: ALA4477128

Type: Binding

Description: Inhibition of human CH24H expressed in Freestyle-293 cells assessed as reduction in 24HC production at 1 uM incubated for 5 hrs using [14C]cholesterol as substrate relative to control

Format: BAO_0000219

Organism: Homo sapiens

Target: Cholesterol 24-hydroxylase(ALA4523510)

Document: ALA4476881

Inhibition of human CH24H expressed in Freestyle-293 cells assessed as reduction in 24HC production at 1 uM incubated for 5 hrs using [14C]cholesterol as substrate relative to control: 38

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4477128

Inhibition

Total(102)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
369.47	2.04	2.04
401.94	3.78	3.78
324.39	1.44	1.44
372.42	3.23	3.23
400.43	2.55	2.55
408.48	3.09	3.09
383.50	2.43	2.43
297.36	1.60	1.60
408.27	2.43	2.43
389.89	2.38	2.38
400.48	2.73	2.73
401.54	2.76	2.76
384.45	2.75	2.75
420.85	2.90	2.90
357.43	2.36	2.36
416.50	4.58	4.58
403.91	2.77	2.77
333.44	3.34	3.34
357.43	2.36	2.36
401.49	2.38	2.38
398.48	3.14	3.14
372.42	3.07	3.07
343.41	1.97	1.97
389.89	2.29	2.29
325.42	2.02	2.02
373.46	3.18	3.18
378.27	2.33	2.33
382.47	1.27	1.27
313.41	1.88	1.88
423.93	1.39	1.39
325.39	2.95	2.95
382.49	2.64	2.64
381.51	3.24	3.24
372.42	3.07	3.07
339.44	2.45	2.45
440.50	3.43	3.43
409.87	3.44	3.44
383.88	3.65	3.65
400.43	2.55	2.55
396.52	3.03	3.03
411.51	3.84	3.84
364.45	2.31	2.31
384.45	2.75	2.75
401.49	2.38	2.38
394.48	1.93	1.93
314.39	2.35	2.35
361.45	3.43	3.43
360.46	2.91	2.91
389.89	2.43	2.43
336.44	2.98	2.98
397.43	3.12	3.12
419.50	3.86	3.86
388.47	3.99	3.99
322.41	2.74	2.74
366.49	3.66	3.66
387.49	3.52	3.52
369.47	2.04	2.04
358.39	2.68	2.68
384.45	2.75	2.75
418.47	2.88	2.88
339.44	2.38	2.38
322.41	2.64	2.64
339.44	2.41	2.41
359.86	2.76	2.76
389.89	2.38	2.38
374.45	2.57	2.57
387.87	2.14	2.14
394.48	1.93	1.93
361.45	2.87	2.87
363.82	2.32	2.32
369.47	2.04	2.04
390.49	2.88	2.88
377.85	2.71	2.71
340.40	2.73	2.73
382.47	1.27	1.27
415.51	2.77	2.77
438.87	1.86	1.86
422.30	2.82	2.82
384.45	2.75	2.75
349.48	3.55	3.55
389.89	2.38	2.38
333.82	2.23	2.23
339.44	2.41	2.41
311.39	2.00	2.00
340.40	2.78	2.78
378.48	2.70	2.70
374.44	3.60	3.60
354.43	3.12	3.12
353.35	2.25	2.25
425.87	2.68	2.68
389.89	2.38	2.38
374.49	3.30	3.30
369.47	2.04	2.04
377.85	2.71	2.71
358.39	2.84	2.84
373.89	3.15	3.15
307.40	2.81	2.81
387.92	3.54	3.54
380.43	2.51	2.51
321.42	3.24	3.24