Basic Information
ID: ALA4477145
Type: Binding
Description: Inhibition of TEV-cleavable hexa-histidine tagged USP28 (1 to 1077 residues) (unknown origin) using ubiquitin-rhodamine 110 as substrate and measured after 90 mins by fluorescence based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4477145
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 429.98 | 3.22 | 3.22 |
| 410.55 | 2.15 | 2.15 |
| 407.54 | 2.71 | 2.71 |
| 463.53 | 3.59 | 3.59 |
| 461.51 | 3.21 | 3.21 |
| 447.51 | 2.86 | 2.86 |
| 445.54 | 3.51 | 3.51 |
| 446.02 | 2.82 | 2.82 |
| 432.55 | 3.38 | 3.38 |
| 424.57 | 2.69 | 2.69 |
| 446.02 | 3.13 | 3.13 |
| 471.58 | 3.94 | 3.94 |
| 499.99 | 3.24 | 3.24 |
| 410.55 | 2.30 | 2.30 |
| 424.57 | 2.64 | 2.64 |
| 435.60 | 3.35 | 3.35 |
| 412.53 | 3.77 | 3.77 |
| 553.61 | 2.97 | 2.97 |
| 380.52 | 3.24 | 3.24 |
| 409.56 | 2.96 | 2.96 |
| 414.51 | 1.98 | 1.98 |
| 395.48 | 2.96 | 2.96 |
| 438.55 | 2.67 | 2.67 |
| 445.54 | 3.24 | 3.24 |
| 456.02 | 3.75 | 3.75 |
| 435.60 | 3.35 | 3.35 |
| 449.62 | 3.88 | 3.88 |
| 489.57 | 4.08 | 4.08 |
| 442.50 | 2.41 | 2.41 |
| 425.56 | 2.58 | 2.58 |
| 409.56 | 2.96 | 2.96 |
| 411.53 | 2.27 | 2.27 |
| 366.49 | 2.81 | 2.81 |
| 438.57 | 4.30 | 4.30 |
| 471.63 | 4.24 | 4.24 |
| 435.60 | 3.45 | 3.45 |
| 494.01 | 3.24 | 3.24 |
| 475.62 | 2.97 | 2.97 |
| 458.03 | 2.75 | 2.75 |
| 409.56 | 2.96 | 2.96 |
| 511.60 | 3.83 | 3.83 |
| 445.54 | 3.51 | 3.51 |
| 421.57 | 3.14 | 3.14 |
| 439.59 | 2.72 | 2.72 |
| 391.88 | 2.86 | 2.86 |
| 482.00 | 3.10 | 3.10 |
| 431.51 | 2.85 | 2.85 |
| 473.61 | 3.03 | 3.03 |
| 449.62 | 3.74 | 3.74 |
| 421.57 | 2.82 | 2.82 |
| 369.45 | 2.79 | 2.79 |
| 485.66 | 4.54 | 4.54 |
| 425.56 | 2.66 | 2.66 |
| 437.57 | 2.34 | 2.34 |
| 449.62 | 3.74 | 3.74 |
| 437.61 | 3.60 | 3.60 |
| 506.08 | 4.89 | 4.89 |
| 407.54 | 2.71 | 2.71 |
| 472.06 | 3.14 | 3.14 |
| 484.43 | 3.36 | 3.36 |
| 506.08 | 4.89 | 4.89 |
| 421.57 | 3.10 | 3.10 |
| 489.62 | 4.38 | 4.38 |
| 568.75 | 4.47 | 4.47 |
| 411.53 | 2.27 | 2.27 |
| 429.98 | 3.22 | 3.22 |
| 409.56 | 3.36 | 3.36 |
| 453.59 | 3.80 | 3.80 |
| 458.03 | 3.10 | 3.10 |
| 449.62 | 3.74 | 3.74 |
| 438.60 | 3.08 | 3.08 |
| 431.51 | 2.85 | 2.85 |
| 451.60 | 2.73 | 2.73 |
| 444.00 | 3.61 | 3.61 |
| 425.56 | 1.93 | 1.93 |
| 423.59 | 3.35 | 3.35 |
| 428.99 | 4.31 | 4.31 |
| 467.60 | 3.27 | 3.27 |
| 427.55 | 2.96 | 2.96 |
| 395.48 | 2.96 | 2.96 |
| 463.53 | 3.55 | 3.55 |
| 471.58 | 3.94 | 3.94 |
| 407.54 | 2.71 | 2.71 |
| 446.53 | 2.78 | 2.78 |
| 438.57 | 4.30 | 4.30 |
| 464.57 | 3.11 | 3.11 |
| 475.54 | 3.77 | 3.77 |
| 463.53 | 3.18 | 3.18 |
| 494.01 | 3.24 | 3.24 |
| 445.54 | 3.24 | 3.24 |
| 431.51 | 2.85 | 2.85 |
| 457.55 | 3.38 | 3.38 |
| 449.50 | 3.28 | 3.28 |
| 396.52 | 1.84 | 1.84 |
| 453.59 | 3.80 | 3.80 |
| 423.59 | 3.70 | 3.70 |
| 471.58 | 3.94 | 3.94 |
| 446.58 | 2.97 | 2.97 |
| 414.96 | 3.97 | 3.97 |
| 423.59 | 3.35 | 3.35 |
| 465.62 | 3.07 | 3.07 |
| 449.62 | 3.74 | 3.74 |
| 417.49 | 2.82 | 2.82 |
| 409.56 | 2.88 | 2.88 |
| 415.95 | 2.91 | 2.91 |
| 429.98 | 3.22 | 3.22 |
| 482.05 | 3.72 | 3.72 |
| 409.56 | 2.88 | 2.88 |
| 437.61 | 3.59 | 3.59 |
| 355.42 | 2.86 | 2.86 |
| 472.62 | 3.63 | 3.63 |
| 446.58 | 2.97 | 2.97 |
| 425.56 | 2.58 | 2.58 |
| 407.54 | 2.57 | 2.57 |
| 409.56 | 2.96 | 2.96 |
| 465.62 | 3.12 | 3.12 |
| 380.52 | 3.24 | 3.24 |
| 437.61 | 3.59 | 3.59 |
| 439.56 | 3.24 | 3.24 |
| 463.65 | 4.13 | 4.13 |
| 405.91 | 2.79 | 2.79 |
| 431.51 | 2.85 | 2.85 |
| 424.57 | 2.33 | 2.33 |
| 445.54 | 3.24 | 3.24 |
| 519.68 | 3.08 | 3.08 |
| 394.54 | 3.63 | 3.63 |
| 545.71 | 3.78 | 3.78 |
| 435.60 | 3.06 | 3.06 |
| 430.52 | 3.90 | 3.90 |
| 433.94 | 3.05 | 3.05 |
| 450.40 | 3.57 | 3.57 |
| 460.61 | 3.53 | 3.53 |
| 425.56 | 2.31 | 2.31 |
| 465.96 | 3.85 | 3.85 |
| 438.56 | 2.22 | 2.22 |
| 463.53 | 3.59 | 3.59 |
| 463.65 | 4.13 | 4.13 |
| 463.53 | 3.55 | 3.55 |
| 445.54 | 3.41 | 3.41 |
| 418.53 | 2.95 | 2.95 |
| 507.56 | 3.17 | 3.17 |
| 431.51 | 3.20 | 3.20 |
| 467.60 | 3.27 | 3.27 |
| 421.57 | 3.10 | 3.10 |
| 444.00 | 3.53 | 3.53 |
| 463.65 | 4.13 | 4.13 |
| 458.03 | 3.10 | 3.10 |
| 409.56 | 2.96 | 2.96 |
| 409.56 | 2.88 | 2.88 |
| 453.59 | 3.80 | 3.80 |
| 395.53 | 2.93 | 2.93 |
| 443.52 | 2.99 | 2.99 |
| 445.54 | 3.41 | 3.41 |
| 437.61 | 3.74 | 3.74 |
| 471.63 | 4.24 | 4.24 |
| 463.53 | 3.18 | 3.18 |
| 423.59 | 3.13 | 3.13 |
| 444.00 | 3.61 | 3.61 |
| 435.60 | 3.45 | 3.45 |
| 435.60 | 3.21 | 3.21 |
| 432.55 | 3.38 | 3.38 |
| 410.55 | 2.15 | 2.15 |
| 428.99 | 4.28 | 4.28 |
| 475.54 | 3.77 | 3.77 |
| 429.98 | 3.22 | 3.22 |
| 489.62 | 4.38 | 4.38 |
| 449.62 | 3.83 | 3.83 |
| 409.56 | 2.96 | 2.96 |
| 472.06 | 3.45 | 3.45 |
| 463.53 | 3.18 | 3.18 |
| 436.52 | 3.09 | 3.09 |
| 413.52 | 2.71 | 2.71 |
| 506.08 | 4.89 | 4.89 |
| 489.62 | 4.38 | 4.38 |
| 510.49 | 2.24 | 2.24 |
| 429.98 | 3.26 | 3.26 |
| 412.53 | 3.77 | 3.77 |
| 447.51 | 2.55 | 2.55 |
| 475.54 | 3.52 | 3.52 |
| 460.61 | 3.53 | 3.53 |
| 423.59 | 3.30 | 3.30 |
| 485.66 | 4.54 | 4.54 |
| 421.57 | 3.10 | 3.10 |
| 449.50 | 2.99 | 2.99 |
| 492.69 | 3.38 | 3.38 |
| 449.50 | 2.99 | 2.99 |
| 471.58 | 3.94 | 3.94 |
| 423.59 | 3.30 | 3.30 |
| 409.56 | 2.96 | 2.96 |
| 453.61 | 2.93 | 2.93 |
| 436.52 | 3.09 | 3.09 |
| 449.98 | 2.71 | 2.71 |
| 435.60 | 3.49 | 3.49 |
| 486.65 | 3.94 | 3.94 |
| 443.52 | 2.99 | 2.99 |
| 447.97 | 3.36 | 3.36 |
| 517.98 | 3.73 | 3.73 |
| 485.66 | 4.54 | 4.54 |
| 445.54 | 3.24 | 3.24 |
| 457.55 | 3.38 | 3.38 |
| 407.54 | 2.71 | 2.71 |
| 449.62 | 3.74 | 3.74 |
| 431.51 | 2.85 | 2.85 |
| 425.56 | 1.93 | 1.93 |
| 463.53 | 3.18 | 3.18 |
| 430.97 | 2.62 | 2.62 |
| 486.09 | 3.66 | 3.66 |
| 458.03 | 2.75 | 2.75 |
| 480.47 | 3.53 | 3.53 |
| 453.59 | 3.80 | 3.80 |
| 456.02 | 3.75 | 3.75 |
| 411.53 | 1.75 | 1.75 |
| 449.62 | 3.74 | 3.74 |
| 465.50 | 2.69 | 2.69 |
| 439.56 | 3.24 | 3.24 |
| 489.57 | 4.08 | 4.08 |
| 413.52 | 2.71 | 2.71 |
| 432.55 | 3.13 | 3.13 |
| 425.56 | 2.31 | 2.31 |
| 446.02 | 3.13 | 3.13 |
| 438.55 | 2.67 | 2.67 |
| 439.59 | 3.05 | 3.05 |
| 395.53 | 2.57 | 2.57 |