Basic Information
ID: ALA4477151
Type: Binding
Description: Inhibition of PHGDH in human MDA-MB-468 cells assessed as reduction in [13C3]-serine production incubated for 180 mins by LC/MS/MS analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: MDA-MB-468
Target: D-3-phosphoglycerate dehydrogenase(ALA2311243)
Document: ALA4476888
Inhibition of PHGDH in human MDA-MB-468 cells assessed as reduction in [13C3]-serine production incubated for 180 mins by LC/MS/MS analysis: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4477151
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.37 | 4.14 | 4.14 |
| 448.93 | 3.49 | 3.49 |
| 555.07 | 2.99 | 2.99 |
| 487.55 | 3.44 | 3.44 |
| 492.98 | 2.94 | 2.94 |
| 487.55 | 3.44 | 3.44 |
| 527.43 | 3.59 | 3.59 |
| 500.36 | 2.51 | 2.51 |
| 463.94 | 2.91 | 2.91 |
| 499.37 | 3.12 | 3.12 |
| 491.01 | 4.36 | 4.36 |
| 505.04 | 4.74 | 4.74 |
| 476.98 | 3.97 | 3.97 |
| 494.52 | 2.57 | 2.57 |
| 497.40 | 4.23 | 4.23 |
| 469.56 | 3.30 | 3.30 |
| 529.59 | 3.07 | 3.07 |
| 474.51 | 2.17 | 2.17 |
| 529.59 | 3.21 | 3.21 |
| 476.00 | 3.67 | 3.67 |
| 494.57 | 3.40 | 3.40 |
| 499.55 | 2.42 | 2.42 |
| 464.93 | 2.46 | 2.46 |
| 505.04 | 4.75 | 4.75 |
| 473.53 | 3.05 | 3.05 |
| 628.15 | 3.47 | 3.47 |
| 514.39 | 2.60 | 2.60 |
| 607.05 | 6.17 | 6.17 |
| 533.05 | 4.13 | 4.13 |
| 541.45 | 3.98 | 3.98 |
| 513.40 | 3.20 | 3.20 |
| 541.45 | 3.98 | 3.98 |
| 570.50 | 4.42 | 4.42 |
| 521.04 | 3.98 | 3.98 |
| 459.50 | 2.66 | 2.66 |
| 478.95 | 2.55 | 2.55 |
| 491.01 | 4.66 | 4.66 |
| 519.02 | 4.04 | 4.04 |
| 521.04 | 3.98 | 3.98 |
| 835.83 | 7.39 | 7.39 |
| 505.04 | 4.60 | 4.60 |
| 533.05 | 3.98 | 3.98 |
| 542.44 | 3.64 | 3.64 |
| 442.50 | 1.92 | 1.92 |
| 537.03 | 2.96 | 2.96 |
| 494.57 | 3.19 | 3.19 |
| 457.51 | 1.50 | 1.50 |
| 533.05 | 4.13 | 4.13 |
| 491.01 | 4.36 | 4.36 |
| 455.54 | 2.91 | 2.91 |
| 573.65 | 1.87 | 1.87 |
| 463.94 | 2.97 | 2.97 |
| 519.06 | 5.14 | 5.14 |
| 529.02 | 3.67 | 3.67 |
| 543.05 | 4.06 | 4.06 |
| 476.00 | 3.49 | 3.49 |
| 923.89 | 6.91 | 6.91 |
| 535.02 | 3.51 | 3.51 |
| 476.98 | 4.27 | 4.27 |
| 519.06 | 5.14 | 5.14 |
| 491.01 | 4.36 | 4.36 |
| 504.99 | 3.84 | 3.84 |
| 492.98 | 2.94 | 2.94 |
| 565.09 | 4.00 | 4.00 |
| 462.96 | 3.58 | 3.58 |
| 488.99 | 4.11 | 4.11 |
| 476.98 | 3.97 | 3.97 |
| 557.07 | 4.45 | 4.45 |
| 557.65 | 2.63 | 2.63 |
| 498.39 | 3.63 | 3.63 |
| 656.21 | 4.24 | 4.24 |
| 495.56 | 2.59 | 2.59 |
| 512.42 | 4.02 | 4.02 |