Basic Information
ID: ALA4477152
Type: Binding
Description: Inhibition of N-terminal HIS-tagged and TEV cleavage site containing full length PHGDH (unknown origin) expressed in Escherichia coli assessed as reduction in conversion of 3-Phosphoglycerate and NAD to 3-Phosphohydroxypyruvate and NADH using 500 uM NAD and 500 uM 3-PG incubated for 240 mins by fluorescence based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4477152
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.37 | 4.14 | 4.14 |
| 497.40 | 3.54 | 3.54 |
| 482.92 | 2.60 | 2.60 |
| 505.04 | 5.05 | 5.05 |
| 483.37 | 3.45 | 3.45 |
| 585.51 | 3.59 | 3.59 |
| 432.93 | 3.82 | 3.82 |
| 466.46 | 2.09 | 2.09 |
| 492.54 | 3.29 | 3.29 |
| 527.43 | 3.59 | 3.59 |
| 557.45 | 2.96 | 2.96 |
| 525.45 | 4.32 | 4.32 |
| 499.37 | 3.12 | 3.12 |
| 533.05 | 2.93 | 2.93 |
| 466.52 | 2.92 | 2.92 |
| 494.52 | 2.57 | 2.57 |
| 483.37 | 3.45 | 3.45 |
| 492.54 | 3.29 | 3.29 |
| 467.37 | 4.48 | 4.48 |
| 497.40 | 3.54 | 3.54 |
| 450.46 | 2.42 | 2.42 |
| 476.50 | 3.35 | 3.35 |
| 491.01 | 3.66 | 3.66 |
| 541.45 | 3.98 | 3.98 |
| 527.43 | 3.89 | 3.89 |
| 491.01 | 4.66 | 4.66 |
| 432.93 | 3.82 | 3.82 |
| 466.92 | 3.63 | 3.63 |
| 549.05 | 1.91 | 1.91 |
| 514.99 | 3.58 | 3.58 |
| 461.47 | 1.55 | 1.55 |
| 509.46 | 5.34 | 5.34 |
| 567.49 | 4.09 | 4.09 |
| 525.45 | 4.32 | 4.32 |
| 497.40 | 3.54 | 3.54 |
| 538.57 | 2.32 | 2.32 |
| 552.60 | 2.56 | 2.56 |
| 483.37 | 3.45 | 3.45 |
| 543.43 | 2.57 | 2.57 |
| 571.48 | 3.34 | 3.34 |
| 550.58 | 2.72 | 2.72 |
| 499.56 | 3.89 | 3.89 |
| 567.49 | 4.09 | 4.09 |
| 525.45 | 4.32 | 4.32 |
| 462.96 | 3.80 | 3.80 |
| 509.41 | 4.37 | 4.37 |
| 450.46 | 2.42 | 2.42 |
| 523.44 | 4.76 | 4.76 |
| 448.93 | 2.80 | 2.80 |
| 524.54 | 1.93 | 1.93 |
| 511.43 | 4.92 | 4.92 |
| 432.93 | 3.82 | 3.82 |
| 594.52 | 4.52 | 4.52 |
| 492.54 | 3.29 | 3.29 |
| 481.40 | 4.57 | 4.57 |
| 510.52 | 1.54 | 1.54 |
| 474.97 | 4.02 | 4.02 |