Basic Information
ID: ALA4477153
Type: Binding
Description: Inhibition of N-terminal HIS-tagged and TEV cleavage site containing full length PHGDH (unknown origin) expressed in Escherichia coli assessed as reduction in conversion of 3-Phosphoglycerate and NAD to 3-Phosphohydroxypyruvate and NADH using 250 uM NAD and 500 uM 3-PG incubated for 240 mins by fluorescence based assay
Format: BAO_0000019
Organism: Homo sapiens
Target: D-3-phosphoglycerate dehydrogenase(ALA2311243)
Document: ALA4476888
Inhibition of N-terminal HIS-tagged and TEV cleavage site containing full length PHGDH (unknown origin) expressed in Escherichia coli assessed as reduction in conversion of 3-Phosphoglycerate and NAD to 3-Phosphohydroxypyruvate and NADH using 250 uM NAD and 500 uM 3-PG incubated for 240 mins by fluorescence based assay: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4477153
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.37 | 4.14 | 4.14 |
| 489.53 | 2.03 | 2.03 |
| 497.40 | 3.54 | 3.54 |
| 503.02 | 4.80 | 4.80 |
| 503.55 | 2.41 | 2.41 |
| 482.92 | 2.60 | 2.60 |
| 462.96 | 2.88 | 2.88 |
| 505.04 | 5.05 | 5.05 |
| 549.05 | 3.10 | 3.10 |
| 492.98 | 2.94 | 2.94 |
| 462.96 | 2.88 | 2.88 |
| 483.37 | 3.45 | 3.45 |
| 508.00 | 2.72 | 2.72 |
| 503.55 | 2.41 | 2.41 |
| 432.93 | 3.82 | 3.82 |
| 466.46 | 2.09 | 2.09 |
| 527.43 | 3.59 | 3.59 |
| 498.61 | 2.46 | 2.46 |
| 497.62 | 4.08 | 4.08 |
| 525.45 | 4.32 | 4.32 |
| 499.37 | 3.12 | 3.12 |
| 533.05 | 2.93 | 2.93 |
| 466.52 | 2.92 | 2.92 |
| 505.04 | 4.74 | 4.74 |
| 476.98 | 3.97 | 3.97 |
| 494.52 | 2.57 | 2.57 |
| 592.11 | 4.47 | 4.47 |
| 497.40 | 4.23 | 4.23 |
| 469.56 | 3.30 | 3.30 |
| 529.59 | 3.07 | 3.07 |
| 483.37 | 3.45 | 3.45 |
| 517.58 | 2.80 | 2.80 |
| 462.96 | 2.88 | 2.88 |
| 464.93 | 2.46 | 2.46 |
| 505.04 | 4.75 | 4.75 |
| 497.40 | 3.54 | 3.54 |
| 508.54 | 2.95 | 2.95 |
| 525.45 | 5.01 | 5.01 |
| 509.00 | 4.50 | 4.50 |
| 491.01 | 3.66 | 3.66 |
| 475.01 | 4.69 | 4.69 |
| 541.45 | 3.98 | 3.98 |
| 553.01 | 2.66 | 2.66 |
| 527.43 | 3.89 | 3.89 |
| 525.00 | 3.47 | 3.47 |
| 501.58 | 3.75 | 3.75 |
| 521.04 | 3.98 | 3.98 |
| 459.50 | 2.66 | 2.66 |
| 491.01 | 4.66 | 4.66 |
| 432.93 | 3.82 | 3.82 |
| 466.92 | 3.63 | 3.63 |
| 485.56 | 2.54 | 2.54 |
| 519.02 | 4.04 | 4.04 |
| 521.04 | 3.98 | 3.98 |
| 549.05 | 1.91 | 1.91 |
| 542.44 | 3.64 | 3.64 |
| 531.61 | 3.19 | 3.19 |
| 514.99 | 3.58 | 3.58 |
| 461.47 | 1.55 | 1.55 |
| 508.98 | 1.91 | 1.91 |
| 492.00 | 3.75 | 3.75 |
| 537.03 | 2.96 | 2.96 |
| 549.05 | 3.10 | 3.10 |
| 525.45 | 4.32 | 4.32 |
| 497.40 | 3.54 | 3.54 |
| 560.80 | 3.79 | 3.79 |
| 449.92 | 2.88 | 2.88 |
| 538.45 | 4.61 | 4.61 |
| 483.37 | 3.45 | 3.45 |
| 517.58 | 3.45 | 3.45 |
| 519.06 | 5.14 | 5.14 |
| 483.37 | 4.14 | 4.14 |
| 529.02 | 3.67 | 3.67 |
| 507.01 | 3.33 | 3.33 |
| 523.01 | 2.57 | 2.57 |
| 535.02 | 3.51 | 3.51 |
| 483.59 | 3.69 | 3.69 |
| 525.45 | 4.32 | 4.32 |
| 462.96 | 3.80 | 3.80 |
| 441.51 | 2.52 | 2.52 |
| 535.02 | 2.71 | 2.71 |
| 491.01 | 4.36 | 4.36 |
| 534.03 | 3.97 | 3.97 |
| 446.96 | 3.91 | 3.91 |
| 535.02 | 2.57 | 2.57 |
| 458.92 | 3.16 | 3.16 |
| 515.56 | 2.68 | 2.68 |
| 549.05 | 2.96 | 2.96 |
| 523.01 | 2.30 | 2.30 |
| 565.09 | 4.00 | 4.00 |
| 462.96 | 3.88 | 3.88 |
| 465.92 | 1.86 | 1.86 |
| 505.54 | 3.58 | 3.58 |
| 448.93 | 2.80 | 2.80 |
| 511.43 | 4.92 | 4.92 |
| 432.93 | 3.82 | 3.82 |
| 446.96 | 3.91 | 3.91 |
| 446.96 | 3.91 | 3.91 |
| 481.40 | 4.57 | 4.57 |
| 474.97 | 4.02 | 4.02 |