Basic Information
ID: ALA4478581
Type: Functional
Description: Inhibition of mRNA splicing of SMN2 exon 7 in C/C-allele mouse harboring FVB.129(B6) Smn1tm5(Smn1/SMN2)Mrph/J assessed as increase in SMN protein level in quadriceps administered orally qd for 10 days measured 1 hr after 10th dose by HTRF assay
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA4478581
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 416.53 | 3.39 | 3.39 |
| 388.48 | 2.38 | 2.38 |
| 392.44 | 2.21 | 2.21 |