Basic Information
ID: ALA4478610
Type: Binding
Description: Inhibition of mRNA splicing of human SMN2 exon 7 transfected in HEK293H cells assessed as compound concentration required to increase full-length SMN2 mRNA level by 1.5 times after 24 hrs by RT-qPCR analysis relative to GAPDH
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4478610
EC1.5
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 334.38 | 4.45 | 4.45 |
| 435.50 | 3.60 | 3.60 |
| 388.47 | 3.93 | 3.93 |
| 415.50 | 2.31 | 2.31 |
| 346.39 | 2.75 | 2.75 |
| 374.45 | 2.04 | 2.04 |
| 336.39 | 2.88 | 2.88 |
| 401.47 | 2.78 | 2.78 |
| 431.54 | 4.04 | 4.04 |
| 389.46 | 2.92 | 2.92 |
| 366.42 | 1.79 | 1.79 |
| 403.49 | 3.26 | 3.26 |
| 352.42 | 2.58 | 2.58 |
| 389.46 | 1.82 | 1.82 |
| 389.46 | 2.92 | 2.92 |
| 375.43 | 3.63 | 3.63 |
| 415.50 | 2.31 | 2.31 |
| 374.44 | 3.08 | 3.08 |
| 366.42 | 1.79 | 1.79 |
| 417.52 | 2.55 | 2.55 |
| 375.43 | 3.63 | 3.63 |
| 389.46 | 1.77 | 1.77 |
| 366.42 | 2.89 | 2.89 |
| 347.37 | 3.01 | 3.01 |
| 306.32 | 3.67 | 3.67 |
| 375.44 | 1.43 | 1.43 |
| 375.43 | 2.53 | 2.53 |
| 389.46 | 2.87 | 2.87 |
| 346.39 | 4.59 | 4.59 |
| 306.36 | 2.87 | 2.87 |
| 361.40 | 2.22 | 2.22 |
| 360.42 | 2.83 | 2.83 |
| 365.43 | 2.62 | 2.62 |
| 366.42 | 1.79 | 1.79 |
| 388.48 | 2.83 | 2.83 |
| 348.36 | 3.44 | 3.44 |
| 367.41 | 2.28 | 2.28 |
| 375.44 | 1.43 | 1.43 |
| 415.50 | 3.40 | 3.40 |
| 366.42 | 2.89 | 2.89 |
| 417.51 | 3.55 | 3.55 |
| 366.42 | 2.02 | 2.02 |
| 389.46 | 2.78 | 2.78 |
| 346.39 | 2.52 | 2.52 |
| 360.42 | 2.83 | 2.83 |
| 376.46 | 3.61 | 3.61 |
| 417.51 | 3.65 | 3.65 |
| 375.43 | 2.53 | 2.53 |
| 401.47 | 2.92 | 2.92 |
| 347.38 | 1.91 | 1.91 |
| 365.43 | 2.39 | 2.39 |
| 366.42 | 1.79 | 1.79 |
| 449.53 | 3.99 | 3.99 |
| 389.46 | 1.82 | 1.82 |
| 388.47 | 3.93 | 3.93 |
| 374.44 | 3.13 | 3.13 |
| 363.44 | 3.48 | 3.48 |