Basic Information
ID: ALA4479083
Type: ADME
Description: Drug activation in human Hep3B cells assessed as human CYP2D6-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NADPH measured after 24 hrs in absence of compound, CYP3A4 and NADPH by cell titer-glo luminescence assay relative to BSO alone
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4479083
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 331.35 | 1.58 | 1.58 |
| 267.37 | 1.61 | 1.61 |
| 180.16 | 1.31 | 1.31 |
| 328.41 | 2.14 | 2.14 |
| 330.75 | 1.89 | 1.89 |
| 253.28 | 1.37 | 1.37 |
| 331.18 | 3.75 | 3.75 |
| 385.51 | 2.09 | 2.09 |
| 375.87 | 4.43 | 4.43 |
| 266.30 | 2.65 | 2.65 |
| 76.05 | -0.96 | -0.96 |
| 137.14 | -0.31 | -0.31 |
| 182.19 | 0.07 | 0.07 |
| 319.88 | 4.81 | 4.81 |
| 261.09 | 1.88 | 1.88 |
| 276.75 | 1.74 | 1.74 |
| 399.44 | 2.87 | 2.87 |
| 236.27 | 3.39 | 3.39 |
| 144.21 | 2.29 | 2.29 |
| 560.69 | 0.92 | 0.92 |
| 179.26 | 2.03 | 2.03 |
| 238.33 | 2.85 | 2.85 |
| 352.77 | 2.81 | 2.81 |
| 244.26 | 3.68 | 3.68 |
| 242.70 | 3.06 | 3.06 |
| 123.11 | 0.78 | 0.78 |
| 613.80 | 2.87 | 2.87 |
| 356.45 | 3.16 | 3.16 |
| 281.36 | 2.84 | 2.84 |
| 123.11 | -0.42 | -0.42 |
| 287.36 | 3.38 | 3.38 |
| 267.24 | -0.20 | -0.20 |
| 331.47 | 1.32 | 1.32 |
| 230.10 | 2.36 | 2.36 |
| 255.36 | 3.35 | 3.35 |
| 151.25 | 1.91 | 1.91 |
| 229.26 | -0.59 | -0.59 |
| 239.31 | 1.31 | 1.31 |
| 167.20 | 0.60 | 0.60 |
| 198.31 | 0.74 | 0.74 |
| 295.38 | 1.53 | 1.53 |
| 211.26 | 1.13 | 1.13 |
| 270.35 | 1.78 | 1.78 |
| 454.45 | 0.27 | 0.27 |
| 230.26 | 3.04 | 3.04 |
| 246.31 | -0.28 | -0.28 |
| 211.22 | -0.50 | -0.50 |
| 218.26 | 0.54 | 0.54 |
| 204.31 | -0.29 | -0.29 |
| 1449.27 | ||
| 249.10 | -1.27 | -1.27 |
| 1202.63 | ||
| 239.75 | 3.30 | 3.30 |
| 720.96 | 5.91 | 5.91 |
| 551.63 | 4.20 | 4.20 |
| 270.21 | 3.25 | 3.25 |
| 224.22 | -0.71 | -0.71 |
| 261.09 | 1.88 | 1.88 |
| 334.17 | 2.89 | 2.89 |
| 365.41 | 0.02 | 0.02 |
| 378.43 | 3.52 | 3.52 |
| 118.16 | -0.22 | -0.22 |
| 337.46 | 4.50 | 4.50 |
| 424.53 | 2.44 | 2.44 |
| 153.14 | 0.67 | 0.67 |
| 301.73 | 4.34 | 4.34 |
| 312.41 | 1.29 | 1.29 |
| 249.27 | 3.60 | 3.60 |
| 242.27 | 3.67 | 3.67 |
| 273.24 | 2.55 | 2.55 |
| 495.75 | 6.88 | 6.88 |
| 286.34 | 1.09 | 1.09 |
| 484.50 | -7.29 | -7.29 |
| 152.18 | 0.64 | 0.64 |
| 822.95 | 4.34 | 4.34 |
| 255.23 | -1.97 | -1.97 |
| 225.21 | -1.33 | -1.33 |
| 457.48 | 0.19 | 0.19 |
| 236.23 | -0.21 | -0.21 |
| 308.33 | 3.61 | 3.61 |
| 136.11 | 0.06 | 0.06 |
| 217.29 | 0.63 | 0.63 |
| 441.40 | -0.04 | -0.04 |
| 244.21 | -3.01 | -3.01 |
| 780.95 | 2.22 | 2.22 |
| 1000.34 | 1.79 | 1.79 |
| 581.58 | -8.16 | -8.16 |
| 226.23 | -0.05 | -0.05 |