Basic Information
ID: ALA4479309
Type: Binding
Description: Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced EtBr uptake measured after 2 hrs by fluorescence analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: P2X purinoceptor 7(ALA4805)
Document: ALA4477234
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced EtBr uptake measured after 2 hrs by fluorescence analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4479309
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 455.47 | 4.19 | 4.19 |
| 687.10 | 5.44 | 5.44 |
| 700.10 | 4.54 | 4.54 |
| 581.70 | 5.41 | 5.41 |
| 600.70 | 4.70 | 4.70 |
| 568.66 | 5.35 | 5.35 |
| 598.68 | 5.36 | 5.36 |
| 616.72 | 4.75 | 4.75 |
| 587.70 | 4.22 | 4.22 |
| 527.95 | 5.04 | 5.04 |
| 615.67 | 4.60 | 4.60 |
| 615.03 | 6.34 | 6.34 |
| 555.66 | 4.96 | 4.96 |
| 542.62 | 4.68 | 4.68 |
| 555.66 | 4.73 | 4.73 |
| 640.08 | 7.62 | 7.62 |
| 642.65 | 2.77 | 2.77 |
| 721.86 | 5.13 | 5.13 |
| 673.11 | 6.36 | 6.36 |
| 605.04 | 6.05 | 6.05 |
| 614.05 | 7.11 | 7.11 |
| 560.00 | 6.98 | 6.98 |
| 557.59 | 4.81 | 4.81 |
| 596.05 | 6.53 | 6.53 |
| 609.75 | 6.19 | 6.19 |
| 553.97 | 6.92 | 6.92 |
| 635.02 | 6.38 | 6.38 |
| 491.90 | 5.62 | 5.62 |
| 689.16 | 6.95 | 6.95 |
| 605.02 | 7.47 | 7.47 |
| 574.66 | 4.16 | 4.16 |
| 648.76 | 4.09 | 4.09 |
| 641.07 | 7.02 | 7.02 |
| 647.08 | 5.83 | 5.83 |
| 640.72 | 2.93 | 2.93 |
| 557.59 | 4.57 | 4.57 |
| 622.73 | 3.56 | 3.56 |
| 596.71 | 5.57 | 5.57 |
| 668.92 | 7.23 | 7.23 |
| 630.73 | 7.14 | 7.14 |
| 563.64 | 5.21 | 5.21 |
| 581.70 | 5.41 | 5.41 |
| 613.74 | 4.75 | 4.75 |
| 675.75 | 2.27 | 2.27 |
| 583.63 | 5.25 | 5.25 |
| 589.63 | 4.06 | 4.06 |
| 580.71 | 6.47 | 6.47 |
| 590.02 | 6.47 | 6.47 |
| 590.68 | 4.07 | 4.07 |
| 615.03 | 6.57 | 6.57 |
| 590.68 | 4.30 | 4.30 |