Basic Information
ID: ALA4479310
Type: Binding
Description: Antagonist activity at human P2X7 receptor in LPS/IFN-gamma-differentiated human THP-1 cells assessed as suppression of BzATP-stimulated IL-1beta release per-incubated for 30 mins before BzATP addition and measured after 30 mins by ELISA
Format: BAO_0000219
Organism: Homo sapiens
Cell type: THP-1
Target: P2X purinoceptor 7(ALA4805)
Document: ALA4477234
Antagonist activity at human P2X7 receptor in LPS/IFN-gamma-differentiated human THP-1 cells assessed as suppression of BzATP-stimulated IL-1beta release per-incubated for 30 mins before BzATP addition and measured after 30 mins by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4479310
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 455.47 | 4.19 | 4.19 |
| 687.10 | 5.44 | 5.44 |
| 700.10 | 4.54 | 4.54 |
| 581.70 | 5.41 | 5.41 |
| 568.66 | 5.35 | 5.35 |
| 616.72 | 4.75 | 4.75 |
| 587.70 | 4.22 | 4.22 |
| 615.03 | 6.34 | 6.34 |
| 555.66 | 4.96 | 4.96 |
| 555.66 | 4.73 | 4.73 |
| 642.65 | 2.77 | 2.77 |
| 721.86 | 5.13 | 5.13 |
| 673.11 | 6.36 | 6.36 |
| 614.05 | 7.11 | 7.11 |
| 557.59 | 4.81 | 4.81 |
| 641.07 | 7.02 | 7.02 |
| 647.08 | 5.83 | 5.83 |
| 640.72 | 2.93 | 2.93 |
| 557.59 | 4.57 | 4.57 |
| 596.71 | 5.57 | 5.57 |
| 613.74 | 4.75 | 4.75 |
| 675.75 | 2.27 | 2.27 |
| 583.63 | 5.25 | 5.25 |
| 589.63 | 4.06 | 4.06 |
| 580.71 | 6.47 | 6.47 |
| 615.03 | 6.57 | 6.57 |
| 590.68 | 4.30 | 4.30 |