Basic Information
ID: ALA4479426
Type: Binding
Description: Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins followed by ATP addition measured after 30 mins by HTRF assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Hepatocyte growth factor receptor(ALA3717)
Document: ALA4477239
Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins followed by ATP addition measured after 30 mins by HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4479426
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 372.39 | 1.67 | 1.67 |
| 341.38 | 2.82 | 2.82 |
| 373.39 | 3.52 | 3.52 |
| 421.41 | 3.12 | 3.12 |
| 373.40 | 3.52 | 3.52 |
| 369.40 | 4.79 | 4.79 |
| 430.42 | 4.03 | 4.03 |
| 357.38 | 2.53 | 2.53 |
| 434.48 | 5.73 | 5.73 |
| 378.87 | 2.80 | 2.80 |
| 458.47 | 4.68 | 4.68 |
| 366.43 | 4.35 | 4.35 |
| 337.39 | 4.09 | 4.09 |
| 359.37 | 3.51 | 3.51 |
| 438.44 | 5.48 | 5.48 |
| 459.46 | 5.11 | 5.11 |
| 437.45 | 6.08 | 6.08 |
| 329.41 | 3.84 | 3.84 |
| 444.45 | 4.42 | 4.42 |
| 323.40 | 2.15 | 2.15 |
| 352.40 | 3.67 | 3.67 |
| 441.47 | 4.88 | 4.88 |
| 369.43 | 3.69 | 3.69 |
| 383.43 | 5.18 | 5.18 |
| 289.38 | 3.96 | 3.96 |
| 330.86 | 2.83 | 2.83 |
| 416.49 | 5.51 | 5.51 |
| 359.37 | 3.51 | 3.51 |
| 387.42 | 3.91 | 3.91 |
| 417.45 | 3.37 | 3.37 |
| 405.38 | 5.11 | 5.11 |
| 416.49 | 5.51 | 5.51 |
| 371.40 | 2.28 | 2.28 |
| 369.43 | 3.69 | 3.69 |
| 440.48 | 4.46 | 4.46 |
| 365.41 | 3.89 | 3.89 |
| 391.39 | 3.66 | 3.66 |
| 387.42 | 3.91 | 3.91 |
| 355.41 | 3.68 | 3.68 |
| 459.46 | 5.11 | 5.11 |
| 355.38 | 4.23 | 4.23 |
| 373.39 | 3.52 | 3.52 |
| 370.39 | 4.18 | 4.18 |
| 421.38 | 4.99 | 4.99 |
| 444.45 | 4.29 | 4.29 |
| 463.42 | 4.85 | 4.85 |
| 327.35 | 2.81 | 2.81 |
| 354.37 | 3.19 | 3.19 |
| 417.45 | 3.37 | 3.37 |
| 293.37 | 2.70 | 2.70 |
| 353.39 | 3.80 | 3.80 |
| 350.40 | 3.20 | 3.20 |
| 434.48 | 5.73 | 5.73 |
| 444.45 | 4.42 | 4.42 |
| 364.42 | 3.46 | 3.46 |
| 387.39 | 4.93 | 4.93 |
| 458.47 | 4.68 | 4.68 |
| 293.37 | 2.70 | 2.70 |
| 341.38 | 2.82 | 2.82 |
| 380.46 | 4.16 | 4.16 |
| 420.45 | 5.34 | 5.34 |
| 373.40 | 3.90 | 3.90 |
| 279.35 | 2.69 | 2.69 |
| 426.46 | 4.20 | 4.20 |
| 383.43 | 5.18 | 5.18 |
| 370.39 | 4.18 | 4.18 |
| 430.42 | 4.03 | 4.03 |
| 355.41 | 3.13 | 3.13 |
| 441.47 | 4.88 | 4.88 |
| 373.40 | 3.90 | 3.90 |
| 403.42 | 2.98 | 2.98 |
| 373.40 | 3.52 | 3.52 |
| 338.37 | 3.48 | 3.48 |
| 388.38 | 4.32 | 4.32 |
| 384.42 | 4.58 | 4.58 |
| 290.37 | 3.36 | 3.36 |
| 445.43 | 4.72 | 4.72 |
| 399.46 | 3.15 | 3.15 |
| 384.42 | 4.58 | 4.58 |
| 430.42 | 4.03 | 4.03 |
| 369.40 | 4.79 | 4.79 |
| 366.43 | 4.35 | 4.35 |
| 419.46 | 5.94 | 5.94 |
| 420.45 | 5.34 | 5.34 |