Basic Information
ID: ALA4479430
Type: ADME
Description: Inhibition of CYP2D6 in human liver microsomes at 10 uM using quinidine as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Cytochrome P450 2D6(ALA289)
Document: ALA4477239
Inhibition of CYP2D6 in human liver microsomes at 10 uM using quinidine as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4479430
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 430.42 | 4.03 | 4.03 |
| 438.44 | 5.48 | 5.48 |
| 373.39 | 3.52 | 3.52 |
| 444.45 | 4.29 | 4.29 |
| 373.40 | 3.52 | 3.52 |