Basic Information
ID: ALA4479462
Type: Binding
Description: Inhibition of EZH2 histone methyltransferase activity of EZH2/EED/SUZ12 protein complex (unknown origin) using histone H3 peptide as substrate (21 to 44 residues) in presence of [3H]-S-adenosylmethionine after 2 hrs by scintillation proximity assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Histone-lysine N-methyltransferase EZH2(ALA2189110)
Document: ALA4477241
Inhibition of EZH2 histone methyltransferase activity of EZH2/EED/SUZ12 protein complex (unknown origin) using histone H3 peptide as substrate (21 to 44 residues) in presence of [3H]-S-adenosylmethionine after 2 hrs by scintillation proximity assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4479462
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 569.75 | 5.09 | 5.09 |
| 555.73 | 4.70 | 4.70 |
| 513.65 | 3.83 | 3.83 |
| 569.75 | 5.09 | 5.09 |
| 511.55 | 5.58 | 5.58 |
| 569.75 | 5.09 | 5.09 |
| 595.79 | 5.31 | 5.31 |
| 609.82 | 6.01 | 6.01 |
| 569.75 | 5.09 | 5.09 |
| 569.75 | 5.09 | 5.09 |
| 555.73 | 4.75 | 4.75 |
| 639.89 | 6.72 | 6.72 |
| 627.83 | 5.06 | 5.06 |
| 541.70 | 4.44 | 4.44 |
| 567.74 | 4.63 | 4.63 |
| 464.61 | 3.30 | 3.30 |
| 583.78 | 5.65 | 5.65 |
| 623.85 | 6.40 | 6.40 |
| 464.61 | 3.66 | 3.66 |
| 442.56 | 5.16 | 5.16 |
| 527.67 | 3.81 | 3.81 |
| 581.77 | 5.02 | 5.02 |
| 583.78 | 5.26 | 5.26 |
| 541.70 | 4.04 | 4.04 |
| 443.55 | 4.56 | 4.56 |
| 543.67 | 3.84 | 3.84 |
| 545.78 | 5.25 | 5.25 |
| 555.73 | 4.70 | 4.70 |
| 597.81 | 5.87 | 5.87 |
| 555.73 | 4.70 | 4.70 |
| 583.78 | 5.33 | 5.33 |
| 583.78 | 5.48 | 5.48 |
| 460.55 | 5.30 | 5.30 |
| 555.73 | 4.70 | 4.70 |
| 569.75 | 5.26 | 5.26 |
| 595.79 | 5.62 | 5.62 |
| 623.85 | 6.09 | 6.09 |
| 583.78 | 5.43 | 5.43 |
| 510.56 | 6.18 | 6.18 |
| 595.79 | 5.79 | 5.79 |
| 609.82 | 5.70 | 5.70 |
| 527.67 | 3.81 | 3.81 |
| 449.60 | 3.96 | 3.96 |
| 617.80 | 5.56 | 5.56 |
| 450.59 | 2.91 | 2.91 |
| 637.87 | 6.48 | 6.48 |
| 528.66 | 3.53 | 3.53 |
| 445.36 | 4.26 | 4.26 |
| 527.67 | 3.81 | 3.81 |
| 514.63 | 3.22 | 3.22 |
| 603.77 | 5.80 | 5.80 |
| 544.66 | 2.82 | 2.82 |
| 461.54 | 4.70 | 4.70 |
| 527.67 | 3.97 | 3.97 |