Basic Information
ID: ALA4479482
Type: Functional
Description: Positive allosteric modulation activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 protein assessed as potentiation of EC20 acetyl choline-induced response by calcium mobilization assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: Muscarinic acetylcholine receptor M4(ALA1821)
Document: ALA4477243
Positive allosteric modulation activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 protein assessed as potentiation of EC20 acetyl choline-induced response by calcium mobilization assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4479482
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 296.39 | 4.03 | 4.03 |
| 282.37 | 3.73 | 3.73 |
| 313.38 | 3.13 | 3.13 |
| 284.34 | 2.52 | 2.52 |
| 316.81 | 4.38 | 4.38 |
| 325.39 | 3.09 | 3.09 |
| 300.38 | 3.28 | 3.28 |
| 327.41 | 2.94 | 2.94 |
| 426.54 | 2.55 | 2.55 |
| 321.35 | 3.25 | 3.25 |
| 286.36 | 2.37 | 2.37 |
| 311.41 | 3.71 | 3.71 |
| 298.37 | 3.43 | 3.43 |
| 402.48 | 3.97 | 3.97 |
| 283.36 | 3.12 | 3.12 |
| 284.38 | 3.58 | 3.58 |
| 359.43 | 3.85 | 3.85 |
| 283.36 | 3.12 | 3.12 |
| 424.53 | 2.70 | 2.70 |
| 285.37 | 2.97 | 2.97 |
| 315.40 | 2.98 | 2.98 |
| 404.50 | 3.82 | 3.82 |
| 285.37 | 2.97 | 2.97 |
| 319.82 | 3.63 | 3.63 |
| 336.82 | 4.37 | 4.37 |
| 320.36 | 3.86 | 3.86 |
| 284.34 | 2.52 | 2.52 |
| 314.41 | 3.59 | 3.59 |
| 286.36 | 2.37 | 2.37 |
| 334.80 | 4.52 | 4.52 |
| 318.35 | 4.00 | 4.00 |
| 317.80 | 3.77 | 3.77 |
| 312.39 | 3.73 | 3.73 |
| 319.34 | 3.40 | 3.40 |
| 318.83 | 4.23 | 4.23 |