Basic Information
ID: ALA4479483
Type: Functional
Description: Positive allosteric modulation activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 protein assessed as potentiation of EC20 acetyl choline-induced response by calcium mobilization assay relative to acetylcholine
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: Muscarinic acetylcholine receptor M4(ALA1821)
Document: ALA4477243
Positive allosteric modulation activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 protein assessed as potentiation of EC20 acetyl choline-induced response by calcium mobilization assay relative to acetylcholine: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4479483
%max
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 296.39 | 4.03 | 4.03 |
| 282.37 | 3.73 | 3.73 |
| 313.38 | 3.13 | 3.13 |
| 284.34 | 2.52 | 2.52 |
| 316.81 | 4.38 | 4.38 |
| 325.39 | 3.09 | 3.09 |
| 311.41 | 3.71 | 3.71 |
| 298.37 | 3.43 | 3.43 |
| 283.36 | 3.12 | 3.12 |
| 359.43 | 3.85 | 3.85 |
| 283.36 | 3.12 | 3.12 |
| 284.34 | 2.52 | 2.52 |
| 334.80 | 4.52 | 4.52 |
| 318.35 | 4.00 | 4.00 |
| 317.80 | 3.77 | 3.77 |
| 312.39 | 3.73 | 3.73 |
| 319.34 | 3.40 | 3.40 |