Basic Information
ID: ALA4481901
Type: Binding
Description: Inhibition of HSP90 in human H1299 cells assessed as reduction in HIF-1alpha at 100 nM incubated for 72 hrs and subsequently incubated under hypoxic conditions for 12 hrs by Western blot analysis relative to control
Format: BAO_0000219
Organism: Homo sapiens
Target: Heat shock protein HSP90(ALA2095165)
Document: ALA4480433
Inhibition of HSP90 in human H1299 cells assessed as reduction in HIF-1alpha at 100 nM incubated for 72 hrs and subsequently incubated under hypoxic conditions for 12 hrs by Western blot analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4481901
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 394.42 | 4.01 | 4.01 |
| 459.54 | 5.74 | 5.74 |
| 383.44 | 4.17 | 4.17 |
| 369.42 | 4.15 | 4.15 |
| 413.47 | 3.54 | 3.54 |
| 387.41 | 4.29 | 4.29 |
| 512.60 | 5.07 | 5.07 |
| 496.61 | 3.19 | 3.19 |
| 370.41 | 3.54 | 3.54 |
| 427.50 | 3.29 | 3.29 |
| 479.96 | 6.53 | 6.53 |
| 480.61 | 5.03 | 5.03 |
| 495.62 | 3.79 | 3.79 |
| 445.49 | 4.33 | 4.33 |
| 455.56 | 3.89 | 3.89 |
| 413.47 | 2.90 | 2.90 |
| 481.59 | 4.33 | 4.33 |
| 441.53 | 3.50 | 3.50 |
| 426.51 | 3.89 | 3.89 |
| 412.49 | 3.50 | 3.50 |
| 477.53 | 5.88 | 5.88 |
| 463.51 | 6.01 | 6.01 |
| 475.54 | 5.88 | 5.88 |
| 474.56 | 5.45 | 5.45 |
| 478.52 | 5.28 | 5.28 |
| 503.60 | 5.76 | 5.76 |
| 469.54 | 3.46 | 3.46 |
| 431.46 | 3.67 | 3.67 |
| 500.57 | 4.01 | 4.01 |
| 483.57 | 3.27 | 3.27 |
| 426.51 | 3.76 | 3.76 |
| 467.57 | 4.03 | 4.03 |
| 401.43 | 4.31 | 4.31 |
| 499.58 | 3.59 | 3.59 |
| 513.61 | 3.93 | 3.93 |
| 460.53 | 5.14 | 5.14 |
| 482.58 | 2.84 | 2.84 |
| 521.59 | 5.90 | 5.90 |
| 427.50 | 3.16 | 3.16 |
| 498.60 | 5.17 | 5.17 |
| 490.56 | 5.15 | 5.15 |
| 494.98 | 5.79 | 5.79 |
| 461.52 | 4.53 | 4.53 |
| 427.50 | 4.19 | 4.19 |
| 414.46 | 2.93 | 2.93 |
| 445.52 | 5.88 | 5.88 |
| 504.58 | 5.16 | 5.16 |
| 444.50 | 4.03 | 4.03 |
| 461.52 | 4.53 | 4.53 |
| 454.52 | 3.68 | 3.68 |
| 455.51 | 3.07 | 3.07 |
| 430.48 | 3.64 | 3.64 |
| 481.59 | 3.45 | 3.45 |
| 384.43 | 3.57 | 3.57 |
| 444.50 | 3.90 | 3.90 |
| 513.59 | 4.46 | 4.46 |
| 459.54 | 6.18 | 6.18 |
| 458.53 | 4.24 | 4.24 |
| 481.59 | 4.42 | 4.42 |
| 494.98 | 5.79 | 5.79 |
| 461.52 | 4.53 | 4.53 |
| 440.54 | 4.11 | 4.11 |
| 469.58 | 4.28 | 4.28 |
| 478.52 | 5.28 | 5.28 |
| 482.58 | 3.88 | 3.88 |
| 428.49 | 3.58 | 3.58 |