Basic Information
ID: ALA4482728
Type: Binding
Description: Inhibition of SPR in human SK-N-BE(2) cells assessed as reduction in BH4 levels incubated for 6 to 48 hrs by LCMS analysis
Format: BAO_0000219
Organism: Homo sapiens
Target: Sepiapterin reductase(ALA3988583)
Document: ALA4482318
Inhibition of SPR in human SK-N-BE(2) cells assessed as reduction in BH4 levels incubated for 6 to 48 hrs by LCMS analysis: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4482728
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 303.37 | 1.44 | 1.44 |
| 313.36 | 1.34 | 1.34 |
| 371.47 | 2.88 | 2.88 |
| 351.39 | -0.56 | -0.56 |
| 391.46 | 3.07 | 3.07 |
| 365.26 | 1.50 | 1.50 |
| 289.34 | 1.05 | 1.05 |
| 371.47 | 2.74 | 2.74 |
| 325.33 | 0.29 | 0.29 |
| 289.34 | 1.05 | 1.05 |
| 303.32 | 0.04 | 0.04 |
| 317.39 | 1.83 | 1.83 |
| 301.35 | 1.24 | 1.24 |
| 379.42 | 1.78 | 1.78 |
| 397.50 | 3.13 | 3.13 |
| 374.40 | 1.94 | 1.94 |
| 335.37 | 1.46 | 1.46 |
| 369.35 | 1.99 | 1.99 |
| 385.37 | 2.40 | 2.40 |
| 371.47 | 2.66 | 2.66 |
| 391.46 | 3.07 | 3.07 |
| 455.52 | 2.21 | 2.21 |
| 344.42 | 0.66 | 0.66 |
| 337.33 | 1.87 | 1.87 |
| 363.42 | 2.33 | 2.33 |
| 377.45 | 2.59 | 2.59 |
| 357.41 | 1.22 | 1.22 |
| 248.24 | 0.36 | 0.36 |
| 397.50 | 3.13 | 3.13 |
| 261.29 | 0.27 | 0.27 |
| 357.44 | 2.49 | 2.49 |
| 377.45 | 2.72 | 2.72 |
| 339.30 | 0.67 | 0.67 |
| 377.43 | 2.37 | 2.37 |
| 498.57 | 0.79 | 0.79 |
| 337.38 | 1.84 | 1.84 |
| 329.40 | 1.44 | 1.44 |
| 363.42 | 2.33 | 2.33 |
| 479.41 | 3.68 | 3.68 |
| 363.42 | 2.33 | 2.33 |
| 425.44 | 3.20 | 3.20 |
| 363.42 | 2.47 | 2.47 |
| 397.38 | 2.58 | 2.58 |
| 329.28 | 1.25 | 1.25 |
| 343.41 | 2.04 | 2.04 |
| 335.37 | 1.46 | 1.46 |
| 397.50 | 3.28 | 3.28 |
| 363.42 | 2.38 | 2.38 |
| 349.39 | 1.77 | 1.77 |
| 363.42 | 2.08 | 2.08 |
| 357.44 | 2.35 | 2.35 |
| 385.43 | 2.62 | 2.62 |
| 391.46 | 3.07 | 3.07 |
| 357.46 | 2.33 | 2.33 |
| 329.40 | 2.06 | 2.06 |
| 369.35 | 1.99 | 1.99 |
| 355.32 | 1.96 | 1.96 |
| 335.37 | 1.78 | 1.78 |
| 391.46 | 2.68 | 2.68 |
| 363.42 | 2.33 | 2.33 |
| 411.41 | 2.89 | 2.89 |
| 335.37 | 1.86 | 1.86 |
| 349.39 | 2.16 | 2.16 |
| 275.31 | 0.66 | 0.66 |
| 403.36 | 2.48 | 2.48 |
| 391.46 | 2.68 | 2.68 |
| 391.46 | 3.07 | 3.07 |
| 335.41 | 2.13 | 2.13 |
| 417.39 | 2.79 | 2.79 |
| 375.43 | 1.95 | 1.95 |
| 349.39 | 1.77 | 1.77 |
| 287.32 | 0.94 | 0.94 |
| 371.47 | 2.88 | 2.88 |
| 336.36 | 0.86 | 0.86 |
| 364.49 | 4.26 | 4.26 |
| 391.48 | 2.76 | 2.76 |
| 289.30 | -0.26 | -0.26 |
| 403.36 | 2.48 | 2.48 |
| 339.36 | 0.49 | 0.49 |
| 425.49 | 3.05 | 3.05 |
| 379.42 | 0.93 | 0.93 |
| 399.52 | 3.38 | 3.38 |
| 315.38 | 1.44 | 1.44 |
| 339.36 | 0.49 | 0.49 |
| 363.42 | 2.08 | 2.08 |
| 385.86 | 3.11 | 3.11 |
| 349.39 | 1.99 | 1.99 |
| 401.49 | 2.51 | 2.51 |
| 349.39 | 2.16 | 2.16 |
| 391.48 | 2.66 | 2.66 |
| 349.39 | 1.77 | 1.77 |
| 369.81 | 2.12 | 2.12 |
| 377.45 | 2.53 | 2.53 |
| 411.41 | 2.89 | 2.89 |
| 363.42 | 2.47 | 2.47 |
| 397.38 | 2.50 | 2.50 |
| 321.34 | 1.47 | 1.47 |
| 391.48 | 2.81 | 2.81 |
| 349.39 | 2.16 | 2.16 |
| 335.37 | 1.73 | 1.73 |