Basic Information
ID: ALA4482729
Type: Binding
Description: Inhibition of SPR in human PBMC cells assessed as reduction in BH4 production incubated for 12 to 48 hrs by LCMS analysis
Format: BAO_0000219
Organism: Homo sapiens
Target: Sepiapterin reductase(ALA3988583)
Document: ALA4482318
Inhibition of SPR in human PBMC cells assessed as reduction in BH4 production incubated for 12 to 48 hrs by LCMS analysis: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4482729
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 388.38 | 1.63 | 1.63 |
| 365.40 | 1.28 | 1.28 |
| 402.41 | 2.17 | 2.17 |
| 388.38 | 1.92 | 1.92 |
| 380.45 | 1.91 | 1.91 |
| 433.39 | 2.22 | 2.22 |
| 502.50 | 1.87 | 1.87 |
| 468.56 | 2.23 | 2.23 |
| 376.37 | 1.63 | 1.63 |
| 352.40 | 1.53 | 1.53 |
| 395.47 | 1.07 | 1.07 |
| 428.46 | 1.61 | 1.61 |
| 374.35 | 1.24 | 1.24 |
| 374.40 | 1.94 | 1.94 |
| 435.45 | 2.95 | 2.95 |
| 467.53 | 2.13 | 2.13 |
| 410.40 | 1.07 | 1.07 |
| 392.39 | 1.84 | 1.84 |
| 421.44 | 2.07 | 2.07 |
| 380.41 | 1.07 | 1.07 |
| 423.40 | 1.23 | 1.23 |
| 441.49 | 1.60 | 1.60 |
| 409.48 | 1.99 | 1.99 |
| 404.42 | 0.92 | 0.92 |
| 427.47 | 1.26 | 1.26 |
| 441.49 | 1.60 | 1.60 |
| 467.53 | 1.99 | 1.99 |
| 366.39 | -0.20 | -0.20 |
| 356.41 | 0.71 | 0.71 |
| 298.31 | 0.36 | 0.36 |
| 423.40 | 1.23 | 1.23 |
| 436.39 | 1.29 | 1.29 |
| 438.41 | 1.68 | 1.68 |
| 449.52 | 1.38 | 1.38 |
| 427.47 | 1.21 | 1.21 |
| 410.36 | 0.23 | 0.23 |
| 379.42 | 1.53 | 1.53 |
| 381.44 | 0.83 | 0.83 |
| 353.39 | 0.93 | 0.93 |
| 449.44 | 1.62 | 1.62 |
| 382.42 | 1.16 | 1.16 |
| 394.48 | 2.15 | 2.15 |
| 398.32 | 1.76 | 1.76 |
| 392.46 | 1.91 | 1.91 |
| 429.48 | 1.62 | 1.62 |
| 383.46 | 1.07 | 1.07 |
| 441.49 | 1.60 | 1.60 |
| 367.41 | 0.44 | 0.44 |
| 434.46 | 1.80 | 1.80 |
| 391.44 | 1.80 | 1.80 |
| 441.49 | 1.60 | 1.60 |
| 380.33 | 1.62 | 1.62 |
| 442.52 | 1.83 | 1.83 |
| 445.47 | 1.85 | 1.85 |
| 403.39 | 0.68 | 0.68 |
| 409.41 | 2.56 | 2.56 |
| 389.42 | 1.59 | 1.59 |
| 441.49 | 1.60 | 1.60 |
| 382.42 | 0.89 | 0.89 |
| 434.42 | 2.71 | 2.71 |
| 403.39 | 0.68 | 0.68 |
| 405.46 | 2.08 | 2.08 |
| 424.38 | 1.70 | 1.70 |
| 409.37 | 0.84 | 0.84 |
| 379.42 | 1.67 | 1.67 |
| 444.50 | 2.17 | 2.17 |
| 383.33 | 1.40 | 1.40 |
| 366.43 | 1.52 | 1.52 |
| 370.41 | 1.16 | 1.16 |
| 375.34 | 0.78 | 0.78 |
| 391.46 | 2.68 | 2.68 |
| 349.39 | 1.77 | 1.77 |
| 374.35 | 1.39 | 1.39 |
| 394.36 | 2.16 | 2.16 |
| 467.53 | 1.99 | 1.99 |
| 417.42 | 1.07 | 1.07 |
| 427.47 | 1.21 | 1.21 |
| 492.38 | 2.22 | 2.22 |
| 449.52 | 1.38 | 1.38 |
| 421.38 | 0.84 | 0.84 |
| 409.49 | 1.46 | 1.46 |
| 394.48 | 2.15 | 2.15 |
| 367.45 | 2.01 | 2.01 |
| 352.40 | 1.24 | 1.24 |
| 368.44 | 0.67 | 0.67 |
| 334.29 | 0.61 | 0.61 |
| 395.39 | 2.17 | 2.17 |
| 365.40 | 1.28 | 1.28 |
| 432.51 | 0.94 | 0.94 |
| 338.37 | 1.14 | 1.14 |
| 472.43 | 1.89 | 1.89 |
| 384.42 | 1.87 | 1.87 |
| 353.39 | 0.13 | 0.13 |
| 367.41 | 0.44 | 0.44 |
| 391.44 | 1.67 | 1.67 |
| 411.41 | 2.89 | 2.89 |
| 438.88 | 1.53 | 1.53 |
| 423.40 | 1.23 | 1.23 |
| 353.43 | 1.77 | 1.77 |
| 388.38 | 1.78 | 1.78 |