Basic Information
ID: ALA4603825
Type: Binding
Description: Irreversible inhibition of ITK in anti-CD3/CD28 beads-stimulated human Jurkat cells assessed as reduction in Plcgamma1 phosphorylation at 3 uM incubated for 2 hrs followed by compound washout with PBS and later stimulated with antiCD3/CD28 for 15 mins by Western blot analysis
Organism: Homo sapiens
Cell type: Jurkat
Activity Charts
Bioactivity
Activity Types for Assay ALA4603825
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 623.85 | 5.69 | 5.69 |
| 543.68 | 5.41 | 5.41 |
| 502.58 | 5.37 | 5.37 |
| 486.52 | 5.92 | 5.92 |