Basic Information
ID: ALA4604697
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 2 min in presence of NADPH by LC-MS/MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Cytochrome P450 3A4(ALA340)
Document: ALA4602676
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 2 min in presence of NADPH by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4604697
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 226.71 | 1.07 | 1.07 |
| 261.15 | 1.86 | 1.86 |
| 240.73 | 1.60 | 1.60 |
| 261.15 | 1.86 | 1.86 |
| 261.15 | 1.86 | 1.86 |
| 275.18 | 2.25 | 2.25 |
| 244.70 | 1.35 | 1.35 |
| 226.71 | 1.21 | 1.21 |
| 226.71 | 1.21 | 1.21 |
| 261.15 | 1.86 | 1.86 |
| 261.15 | 1.86 | 1.86 |
| 261.15 | 1.72 | 1.72 |
| 261.15 | 1.86 | 1.86 |