Basic Information
ID: ALA4613065
Type: Functional
Description: Inhibition of EED in SCID mouse xenografted with human KARPAS422 cells assessed as reduction in H3K27me3 level in tumor at 100 mg/kg, po dosed as single administration measured after 24 hrs by Western blotting analysis
Format: BAO_0000218
Organism: Mus musculus
Cell type: KARPAS-422
Target: Polycomb protein EED(ALA2189117)
Document: ALA4610126
Inhibition of EED in SCID mouse xenografted with human KARPAS422 cells assessed as reduction in H3K27me3 level in tumor at 100 mg/kg, po dosed as single administration measured after 24 hrs by Western blotting analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4613065
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 467.53 | 3.50 | 3.50 |
| 479.54 | 3.76 | 3.76 |